Clinical spectrum of central nervous system tuberculosis and the efficacy of revised national tuberculosis control program in its management

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus. Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB tr...

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Bibliographic Details
Published in:Journal of neurosciences in rural practice 2019-01, Vol.10 (1), p.71-77
Main Authors: Maheswari, E, Bhoopathy, R, Bhanu, K, Anandan, Heber
Format: Article
Language:English
Subjects:
Age
Analysis
Care and treatment
Central nervous system
Clinical outcomes
Drug resistance
Health aspects
Hematology
HIV
Human immunodeficiency virus
Illnesses
Infections
Medical imaging
Meningitis
NMR
Nuclear magnetic resonance
Original
Patient outcomes
Patients
Phosphatase
Practice guidelines (Medicine)
Substance abuse treatment
Treatment outcome
Tuberculosis
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Summary:Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus. Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS). Materials and Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Results: The outcome of management with the standard RNTCP DOTS regimen was that a success rate (treatment completed) of 75%, the default rate of 6.6%, and a mortality of 3.3%. The target fixed by the RNTCP is to achieve a cure rate of 85%. We were able to document successful completion of treatment in 75% which is close to the target fixed by RNTCP. The default rate is 6.6% which quite negligible when compared to the unsupervised therapy which has a default rate of 50%. Conclusion: The most important factor in predicting the outcome of treatment in CNS-TB is early diagnosis and the timing of initiation of antituberculous treatment. Early initiation of treatment is associated with better treatment outcomes.
ISSN:0976-3147
0976-3155
DOI:10.4103/jnrp.jnrp_163_18