Nutritional content of selected species of tropical eggplant fruit (Solanum spp) diet Attenuates hepatic inflammation in high‐fat fed male Wistar rats induced with streptozotocin

Tropical Solanum species contains a high level of phenolic acids and flavonoids, which were found to inhibit some key enzymes associated with the incidence of type 2 diabetes in in vitro and in vivo models based on earlier studies. This study was further designed to compare the nutritional propertie...

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Bibliographic Details
Published in:Food science & nutrition 2019-01, Vol.7 (1), p.109-119
Main Authors: Nwanna, Esther Emem, Ibukun, Emmanuel O., Oboh, Ganiyu
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Animal models
Antioxidants
Aspartate aminotransferase
Biomarkers
Catalase
Cholesterol
Creatinine
Density
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diet
Enzymes
Flavonoids
Fruits
glycemic index
High fat diet
hypolipidemia
In vivo methods and tests
Inflammation
Kidneys
Lipids
Lipoproteins
Liver
nephrotoxicity
nutritional output
Original Research
Phenolic acids
Phenols
Restoration
Rodents
Solanum
Solanum aethiopicum
Solanum gilo
Solanum kumba
Species
Streptozocin
streptozotocin
Superoxide dismutase
Triglycerides
Tropical eggplant
Urea
Uric acid
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Summary:Tropical Solanum species contains a high level of phenolic acids and flavonoids, which were found to inhibit some key enzymes associated with the incidence of type 2 diabetes in in vitro and in vivo models based on earlier studies. This study was further designed to compare the nutritional properties, glycemic index, and hypolipidemic and the antioxidant effects of three species of tropical eggplant fruit (Solanum kumba, Solanum aethiopicum, and Solanum gilo) diet on streptozotocin (STZ)‐induced nephrotoxicity in male Wistar rats. The animal model was subjected to high‐fat diet prior to interperitional administration of streptozotocin (35 mg/kg wt); thereafter, the rats were given supplemented eggplant fruit diet, which lasted for 14 days. Determination of lipid content [triglycerides (TG), low‐density lipoproteins (LDLs), high‐density lipoproteins (HDLs), and total cholesterol (TC)], was assessed, while the liver biomarker enzymes alanine aminotransferase (ALT) alkaline phosphatase (ALP) and aspartate aminotransferase (AST), also endogenous enzymes such as superoxide dismutase (SOD) and catalase (CAT), were determined. Histopathological assessment of inflammation was carried out on kidney while the blood urea nitrogen (BUN), uric acid, and creatinine level on the kidney function were determined. The results showed that the groups with supplemented eggplant diet had significant (p 
ISSN:2048-7177
2048-7177
DOI:10.1002/fsn3.811