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Orbital precursor B-lymphoblastic lymphoma involving the extraocular muscles in a 56-year-old male and a review of the literature
The aim of the present study was to describe a rare case of orbital precursor B-lymphoblastic lymphoma (B-LBL) in an adult. A 56-year-old male in complete remission of a gastric precursor B-LBL was referred to our orbital clinic due to rapid development of left-sided painless periorbital swelling, d...
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Published in: | Oncology letters 2019-02, Vol.17 (2), p.1477-1482 |
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description | The aim of the present study was to describe a rare case of orbital precursor B-lymphoblastic lymphoma (B-LBL) in an adult. A 56-year-old male in complete remission of a gastric precursor B-LBL was referred to our orbital clinic due to rapid development of left-sided painless periorbital swelling, diplopia, and proptosis. Complete ophthalmoplegia was observed. Notably, magnetic resonance imaging showed swelling of the medial and inferior rectus muscles in the left orbit and biopsies were performed. Following histological diagnosis of precursor B-LBL, the patient was treated with radiotherapy (2Gy × 20) and chemotherapy according to the NOPHO ALL 2008 protocol. The disease progressed and the patient succumbed after 5 months. Histomorphologically, a lymphoblastic infiltrate was observed within the skeletal muscle tissue. The tumor cells were small and immature, and stained strongly for cluster of differentiating (CD)10, CD79a, paired box 5 and B cell lymphoma-2. The Ki-67 proliferative index was 90%. Multiplex ligation-dependent probe amplification and array comparative genomic hybridization detected whole chromosomal gain of X and 12, and both hemizygous and homozygous deletion on 9p comprising cyclin dependent kinase inhibitor 2A/B. Furthermore, array comparative genomic hybridization detected copy number imbalances consisting of focal or smaller deletions on chromosomes 1, 9, 10, 11 and 20. The final diagnosis was precursor B-LBL relapse in the extraocular muscles. Orbital precursor B-LBL is extremely rare in adults, and the diagnosis may be challenging to make. It is recommended to obtain material for cytogenetic and molecular analyses. |
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A 56-year-old male in complete remission of a gastric precursor B-LBL was referred to our orbital clinic due to rapid development of left-sided painless periorbital swelling, diplopia, and proptosis. Complete ophthalmoplegia was observed. Notably, magnetic resonance imaging showed swelling of the medial and inferior rectus muscles in the left orbit and biopsies were performed. Following histological diagnosis of precursor B-LBL, the patient was treated with radiotherapy (2Gy × 20) and chemotherapy according to the NOPHO ALL 2008 protocol. The disease progressed and the patient succumbed after 5 months. Histomorphologically, a lymphoblastic infiltrate was observed within the skeletal muscle tissue. The tumor cells were small and immature, and stained strongly for cluster of differentiating (CD)10, CD79a, paired box 5 and B cell lymphoma-2. The Ki-67 proliferative index was 90%. Multiplex ligation-dependent probe amplification and array comparative genomic hybridization detected whole chromosomal gain of X and 12, and both hemizygous and homozygous deletion on 9p comprising cyclin dependent kinase inhibitor 2A/B. Furthermore, array comparative genomic hybridization detected copy number imbalances consisting of focal or smaller deletions on chromosomes 1, 9, 10, 11 and 20. The final diagnosis was precursor B-LBL relapse in the extraocular muscles. Orbital precursor B-LBL is extremely rare in adults, and the diagnosis may be challenging to make. It is recommended to obtain material for cytogenetic and molecular analyses.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2018.9725</identifier><identifier>PMID: 30675202</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Bone marrow ; Care and treatment ; Case studies ; Chemotherapy ; Chromosomes ; Cloning ; Deoxyribonucleic acid ; Diagnosis ; DNA ; Genomes ; Hybridization ; Lymphoma ; Lymphomas ; NMR ; Nuclear magnetic resonance ; Oncology ; Pain ; Tumors ; Young adults</subject><ispartof>Oncology letters, 2019-02, Vol.17 (2), p.1477-1482</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright: © Ejstrup et al. 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-6622ded34877b076a46c5c1a439d5e5c060a2739ea7621192e0a94ce53f6bcdf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341779/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341779/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30675202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ejstrup, Rasmus</creatorcontrib><creatorcontrib>Mikkelsen, Lauge Hjorth</creatorcontrib><creatorcontrib>Andersen, Mette Klarskov</creatorcontrib><creatorcontrib>Clasen-Linde, Erik</creatorcontrib><creatorcontrib>Gjerdrum, Lise Mette Rahbek</creatorcontrib><creatorcontrib>Safavi, Setareh</creatorcontrib><creatorcontrib>Heegaard, Steffen</creatorcontrib><title>Orbital precursor B-lymphoblastic lymphoma involving the extraocular muscles in a 56-year-old male and a review of the literature</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>The aim of the present study was to describe a rare case of orbital precursor B-lymphoblastic lymphoma (B-LBL) in an adult. A 56-year-old male in complete remission of a gastric precursor B-LBL was referred to our orbital clinic due to rapid development of left-sided painless periorbital swelling, diplopia, and proptosis. Complete ophthalmoplegia was observed. Notably, magnetic resonance imaging showed swelling of the medial and inferior rectus muscles in the left orbit and biopsies were performed. Following histological diagnosis of precursor B-LBL, the patient was treated with radiotherapy (2Gy × 20) and chemotherapy according to the NOPHO ALL 2008 protocol. The disease progressed and the patient succumbed after 5 months. Histomorphologically, a lymphoblastic infiltrate was observed within the skeletal muscle tissue. The tumor cells were small and immature, and stained strongly for cluster of differentiating (CD)10, CD79a, paired box 5 and B cell lymphoma-2. The Ki-67 proliferative index was 90%. Multiplex ligation-dependent probe amplification and array comparative genomic hybridization detected whole chromosomal gain of X and 12, and both hemizygous and homozygous deletion on 9p comprising cyclin dependent kinase inhibitor 2A/B. Furthermore, array comparative genomic hybridization detected copy number imbalances consisting of focal or smaller deletions on chromosomes 1, 9, 10, 11 and 20. The final diagnosis was precursor B-LBL relapse in the extraocular muscles. Orbital precursor B-LBL is extremely rare in adults, and the diagnosis may be challenging to make. It is recommended to obtain material for cytogenetic and molecular analyses.</description><subject>Age</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Chemotherapy</subject><subject>Chromosomes</subject><subject>Cloning</subject><subject>Deoxyribonucleic acid</subject><subject>Diagnosis</subject><subject>DNA</subject><subject>Genomes</subject><subject>Hybridization</subject><subject>Lymphoma</subject><subject>Lymphomas</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oncology</subject><subject>Pain</subject><subject>Tumors</subject><subject>Young adults</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNptks1vFCEYxidGY5vam2dDYmI8OCsfA8xcTGrjV9KkFz0Thnlnh4aBFWZW99j_vEy3rl0jHICX3_sAL09RvCR4xeqGvg9uRTGpV42k_ElxSmRDS4Jr-vQwl9VJcZ7SDc6NC1LX4nlxwrCQnGJ6Wtxex9ZO2qFNBDPHFCL6WLrduBlC63SarEH71aiR9dvgttav0TQAgt9T1MHMTkc0zsk4SJlAGnFR7kDHMrgOjdoB0r7L4QhbC79Q6O-znZ0g6mmO8KJ41muX4PxhPCt-fP70_fJreXX95dvlxVVpOMFTKQSlHXSsqqVssRS6EoYboivWdBy4wQJrKlkDWgpKSEMB66YywFkvWtP17Kz4sNfdzO0InQGf7-_UJtpRx50K2qrjHW8HtQ5bJVhFpGyywNsHgRh-zpAmNdpkwDntIcxJ0Vxx1lQ1W9DX_6A3YY4-P2-hKlLlTyN_qXWukrK-D_lcs4iqCy4rRji-11r9h8q9g9Ga4KG3OX6U8OZRwgDaTUMKbp5s8OkYfLcHTQwpRegPxSBYLfZSwanFXmqxV8ZfPS7gAf5jJnYH2BPKFw</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Ejstrup, Rasmus</creator><creator>Mikkelsen, Lauge Hjorth</creator><creator>Andersen, Mette Klarskov</creator><creator>Clasen-Linde, Erik</creator><creator>Gjerdrum, Lise Mette Rahbek</creator><creator>Safavi, Setareh</creator><creator>Heegaard, Steffen</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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Multiplex ligation-dependent probe amplification and array comparative genomic hybridization detected whole chromosomal gain of X and 12, and both hemizygous and homozygous deletion on 9p comprising cyclin dependent kinase inhibitor 2A/B. Furthermore, array comparative genomic hybridization detected copy number imbalances consisting of focal or smaller deletions on chromosomes 1, 9, 10, 11 and 20. The final diagnosis was precursor B-LBL relapse in the extraocular muscles. Orbital precursor B-LBL is extremely rare in adults, and the diagnosis may be challenging to make. It is recommended to obtain material for cytogenetic and molecular analyses.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>30675202</pmid><doi>10.3892/ol.2018.9725</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Age Bone marrow Care and treatment Case studies Chemotherapy Chromosomes Cloning Deoxyribonucleic acid Diagnosis DNA Genomes Hybridization Lymphoma Lymphomas NMR Nuclear magnetic resonance Oncology Pain Tumors Young adults |
title | Orbital precursor B-lymphoblastic lymphoma involving the extraocular muscles in a 56-year-old male and a review of the literature |
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