Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance

The Cys 6 Zn 2 DNA-binding domain transcription factor Pdr1 is a central regulator of drug resistance in the pathogenic yeast Candida glabrata . In this review, I discuss the multiple control mechanisms modulating the function of this positive transcriptional regulator. Available data suggest that P...

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Bibliographic Details
Published in:Current genetics 2019-02, Vol.65 (1), p.103-108
Main Author: Moye-Rowley, W. Scott
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antifungal agents
Azoles - pharmacology
Baking yeast
Binding Sites - genetics
Biochemistry
Biomedical and Life Sciences
Candida glabrata
Candida glabrata - genetics
Candida glabrata - metabolism
Cell Biology
Deoxyribonucleic acid
DNA
DNA-binding domains
DNA-Binding Proteins - genetics
DNA-Binding Proteins - metabolism
Drug resistance
Drug Resistance, Fungal - genetics
Fungal Proteins - genetics
Fungal Proteins - metabolism
Gene Expression Regulation, Fungal
Interfaces
Life Sciences
Microbial Genetics and Genomics
Microbiology
Mini-Review
Mutagenesis
Mutation
Physiological effects
Plant Sciences
Proteins
Proteomics
Resistance factors
Saccharomyces cerevisiae
transactivators
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
Yeasts
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Summary:The Cys 6 Zn 2 DNA-binding domain transcription factor Pdr1 is a central regulator of drug resistance in the pathogenic yeast Candida glabrata . In this review, I discuss the multiple control mechanisms modulating the function of this positive transcriptional regulator. Available data suggest that Pdr1 activity is restrained by multiple negative inputs that can be lost by either mutagenesis of the protein or loss of trans-acting factors. Although extensive data are available on the C. glabrata transactivator as well as its cognate proteins in Saccharomyces cerevisiae , the physiological rationale underlying the regulation of these factors remains to be understood.
ISSN:0172-8083
1432-0983
DOI:10.1007/s00294-018-0870-4