Graphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing

Graphene oxide (GO), the most common derivative of graphene, is an exceptional nanomaterial that possesses multiple physical properties critical for biomedical applications. GO exhibits pH-dependent fluorescence emission in the visible/near-infrared, providing a possibility of molecular imaging and...

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Bibliographic Details
Published in:Scientific reports 2019-01, Vol.9 (1), p.416, Article 416
Main Authors: Campbell, E., Hasan, Md. Tanvir, Pho, Christine, Callaghan, K., Akkaraju, G. R., Naumov, A. V.
Format: Article
Language:English
Subjects:
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Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cancer
Cytotoxicity
Drug Delivery Systems
Emissions
Fluorescence
Graphite - chemistry
Graphite - pharmacology
HEK293 Cells
HeLa Cells
Humanities and Social Sciences
Humans
Internalization
MCF-7 Cells
Microenvironments
Microscopy, Fluorescence
multidisciplinary
Nanostructures - chemistry
Nanostructures - therapeutic use
Neoplasms - diagnostic imaging
Neoplasms - drug therapy
pH effects
Physical properties
Science
Science (multidisciplinary)
Tumor Microenvironment - drug effects
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Summary:Graphene oxide (GO), the most common derivative of graphene, is an exceptional nanomaterial that possesses multiple physical properties critical for biomedical applications. GO exhibits pH-dependent fluorescence emission in the visible/near-infrared, providing a possibility of molecular imaging and pH-sensing. It is also water soluble and has a substantial platform for functionalization, allowing for the delivery of multiple therapeutics. GO physical properties are modified to enhance cellular internalization, producing fluorescent nanoflakes with low (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-36617-4