Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis: An Observational Cohort Study

RATIONALE:Psoriasis is a systemic inflammatory skin disease associated with cardiovascular disease and lipid dysfunction. However, traditional lipid parameters have limited prognostic value, whereas assessing oxidation-modified lipids in this inflammatory driven condition may capture additional risk...

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Published in:Circulation research 2018-11, Vol.123 (11), p.1244-1254
Main Authors: Sorokin, Alexander V, Kotani, Kazuhiko, Elnabawi, Youssef A, Dey, Amit K, Sajja, Aparna P, Yamada, Shingo, Ueda, Masashi, Harrington, Charlotte L, Baumer, Yvonne, Rodante, Justin A, Gelfand, Joel M, Chen, Marcus Y, Joshi, Aditya A, Playford, Martin P, Remaley, Alan T, Mehta, Nehal N
Format: Article
Language:English
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Summary:RATIONALE:Psoriasis is a systemic inflammatory skin disease associated with cardiovascular disease and lipid dysfunction. However, traditional lipid parameters have limited prognostic value, whereas assessing oxidation-modified lipids in this inflammatory driven condition may capture additional risk. Recently, a study showed that psoriasis was associated with increased lipid-rich coronary plaques; therefore, investigating potential relationships with oxidation-modified lipids may speed understanding of increased cardiovascular disease in psoriasis. OBJECTIVE:To understand whether oxidation-modified lipids associate with traditional lipid phenotypes, cardiometabolic disease biomarkers, and total coronary plaque, with focus on noncalcified burden (NCB) by coronary computed tomographic angiography in psoriasis. METHODS AND RESULTS:Psoriasis subjects and controls (n=252) had profiling for oxidation-modified LDL (low-density lipoprotein), HDL (high-density lipoprotein), Lp(a) (lipoprotein[a]), cholesterol efflux capacity, lipoprotein particle size and number by NMR spectroscopy, and PON-1 (paraoxonase-1) activity. Blinded coronary computed tomographic angiography coronary artery disease characterization included total burden, NCB, and dense-calcified burden. Compared with healthy volunteers, psoriasis subjects were older (mean age, 50.1), had increased body mass index, and homeostatic model assessment of insulin resistance. Psoriasis subjects had increase in oxidized Lp(a), Lp(a), and oxidized HDL (oxHDL; P
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.118.313608