Survival analysis of adult and children intermittent exotropia using a matched case-control design

• Published in: Scientific reports 2019-01, Vol.9 (1), p.575-575, Article 575
• Main Authors: Choi, Daye Diana, Noh, Hoon, Park, Kyung-Ah, Oh, Sei Yeul
• Format: Article
• Language: English
• Subjects: 692/308/3187; 692/308/409; Children; Humanities and Social Sciences; multidisciplinary; Patients; Regression analysis; Risk factors; Science; Science (multidisciplinary); Surgery; Surgical outcomes; Survival; Survival analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-38160-8

To compare the surgical outcomes of adult intermittent exotropia (X(T)) patients and matched control children X(T) patients including survival analysis. Fifty-two adult X(T) patients and 129 matched control children X(T) patients were included. Clinical characteristics, survival analysis, and surgical dose-response curves were evaluated and compared between the two groups. The weighted Cox proportional hazards regression analysis was used in order to find risk factors for the recurrence. Using Kaplan-Meier survival analysis, the cumulative probability of survival rate considering recurrence as event of Adult group were 93.97% for one year, and maintained at 88.44% for two, three. four, and five years after surgery. In contrast, those of the Child group were 83.6%, 76.5%, 65.6%, 56.23%, and 40.16% for one, two, three, four, and five years after surgery, respectively. The Adult group had a better event-free survival curve than the Child group as analyzed by a Log-rank test (p = 0.020). According to multivariate weighted Cox regression analysis, the younger age at operation and the larger preoperative angle were significant risk factors for recurrence.