Risk Factors for Delayed Antimicrobial Treatment in Febrile Children with Urinary Tract Infections

• Published in: The Journal of pediatrics 2019-02, Vol.205, p.126-129
• Main Authors: Hum, Stephanie W., Shaikh, Nader
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - therapeutic use; Child, Preschool; Female; Fever - drug therapy; Fever - etiology; Follow-Up Studies; Humans; Infant; Male; Prospective Studies; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Time-to-Treatment; urinary tract infection; Urinary Tract Infections - complications; Urinary Tract Infections - drug therapy; UTI; Vesico-Ureteral Reflux - complications
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2018.09.029

To identify factors associated with delayed antimicrobial treatment in febrile children with urinary tract infection (UTI). We reviewed data from 802 children with UTI enrolled in 2 previously conducted prospective studies (Randomized Intervention for Children with Vesicoureteral Reflux and Careful Urinary Tract Infection Evaluation) and extracted data on possible predictors of delayed treatment including age, sex, history of UTI, ethnicity, race, primary caregiver's education level, insurance, and income. We used univariate and multivariable analyses to investigate the relationship between these predictors and treatment delay. We included 660 febrile patients with a mean age of 17.0 months old. Older age and commercial insurance were associated with delayed treatment on univariate analysis. Compared with younger children, treatment was delayed by an average of 26.2 hours in children ≥12 months of age. This relationship remained significant on multivariable analysis. Treatment also was delayed by an average of 12.6 hours in patients with commercial insurance. Race, ethnicity, primary caregiver's education level, and income were not associated with delayed treatment. Older age was a consistent predictor of delayed antimicrobial treatment. Delays in the initiation of antimicrobial therapy for UTI has previously been associated with renal scarring. Educating parents with older children regarding the management of fever as well as providers regarding prompt evaluation and management may help to reduce renal scarring.