Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging

Near-infrared II fluorescence imaging holds great promise for imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which lar...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2019-01, Vol.10 (4), p.1219-1226
Main Authors: Lin, Jiacheng, Zeng, Xiaodong, Xiao, Yuling, Tang, Lin, Nong, Jinxia, Liu, Yufang, Zhou, Hui, Ding, Bingbing, Xu, Fuchun, Tong, Hanxing, Deng, Zixin, Hong, Xuechuan
Format: Article
Language:English
Subjects:
Agglomeration
Aqueous solutions
Biocompatibility
Biomedical materials
Blood vessels
Chemistry
Emission analysis
Fluorescence
Gastrointestinal system
In vivo methods and tests
Infrared imaging
Ischemia
Medical imaging
Nanoparticles
Near infrared radiation
Temporal resolution
Tumors
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Summary:Near-infrared II fluorescence imaging holds great promise for imaging and imaging-guided surgery with deep penetration and high spatiotemporal resolution. However, most NIR-II aromatic luminophores suffer from the notorious aggregation-caused quenching (ACQ) effect in the aqueous solution, which largely hinders their biomedical application . In this study, the first NIR-II organic aggregation-induced emission (AIE) fluorophore ( ), encapsulated as nanoparticles ( dots) for biomedical imaging, was designed and synthesized. The NIR-II AIE dots showed high temporal resolution, high photostability, outstanding water-solubility and biocompatibility and . The dots were further used for long-term breast tumor imaging and visualizing tumor-feeding blood vessels, long-term hind limb vasculature and incomplete hind limb ischemia. More importantly, as a proof-of-concept, this is the first time that non-invasive and real-time NIR-II imaging of the gastrointestinal tract in health and disease has been performed, making the AIE dots a promising tool for gastrointestinal (GI) tract research, such as understanding the healthy status of GI peristalsis, diagnosing and evaluating intestinal motility dysfunction, and assessing drug effects on intestinal obstruction.
ISSN:2041-6520
2041-6539
DOI:10.1039/c8sc04363a