Oncostatin M and its role in fibrosis

Oncostain M, a member of the IL-6 family of cytokines, is produced by immune cells in response to infections and tissue injury. OSM has a broad, often context-dependent effect on various cellular processes including differentiation, hematopoiesis, cell proliferation, and cell survival. OSM signaling...

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Bibliographic Details
Published in:Connective tissue research 2019-01, Vol.60 (1), p.40-49
Main Authors: Stawski, Lukasz, Trojanowska, Maria
Format: Article
Language:English
Subjects:
Animals
ECM
Fibrosis
Humans
inflammation
Inflammation - pathology
Models, Biological
Oncostatin M - metabolism
OSM
Signal Transduction
vascular injury
Vascular System Injuries - metabolism
Vascular System Injuries - pathology
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Summary:Oncostain M, a member of the IL-6 family of cytokines, is produced by immune cells in response to infections and tissue injury. OSM has a broad, often context-dependent effect on various cellular processes including differentiation, hematopoiesis, cell proliferation, and cell survival. OSM signaling is initiated by binding to type I (LIFRβ/gp130) or type II (OSMRβ/gp130) receptor complexes and involves activation of Janus kinase/signal transducer and activator of transcription, mitogen-activated protein kinase, and phosphatidylinositol-3-kinase. High levels of OSM have been detected in many chronic inflammatory conditions characterized by fibrosis, giving a rationale to target OSM for the treatment of these diseases. Here we discuss the current knowledge on the role of OSM in various stages of the fibrotic process including inflammation, vascular dysfunction, and activation of fibroblasts.
ISSN:0300-8207
1607-8438
DOI:10.1080/03008207.2018.1500558