Manually-parcellated gyral data accounting for all known anatomical variability

• Published in: Scientific data 2019-01, Vol.6 (1), p.190001-190001, Article 190001
• Main Authors: Mikhael, Shadia S., Mair, Grant, Valdes-Hernandez, Maria, Hoogendoorn, Corné, Wardlaw, Joanna M., Bastin, Mark E., Pernet, Cyril
• Format: Article
• Language: English
• Subjects: 631/378/2612; 631/378/2649; 692/617; Aging; Aging - pathology; Aging - physiology; Brain - anatomy & histology; Brain - pathology; Data Descriptor; Female; Frontal gyrus; Gyrus Cinguli - anatomy & histology; Gyrus Cinguli - pathology; Humanities and Social Sciences; Humans; Image processing; Magnetic Resonance Imaging; Male; Middle Aged; multidisciplinary; Parietal Lobe - anatomy & histology; Parietal Lobe - pathology; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - pathology; Science; Substantia alba; Substantia grisea
• ISSN: 2052-4463; 2052-4463
• DOI: 10.1038/sdata.2019.1

Morphometric brain changes occur throughout the lifetime and are often investigated to understand healthy ageing and disease, to identify novel biomarkers, and to classify patient groups. Yet, to accurately characterise such changes, an accurate parcellation of the brain must be achieved. Here, we present a manually-parcellated dataset of the superior frontal, the supramarginal, and the cingulate gyri of 10 healthy middle-aged subjects along with a fully detailed protocol based on two anatomical atlases. Gyral parcels were hand-drawn then reviewed by specialists blinded from the protocol to ensure consistency. Importantly, we follow a procedure that allows accounting for anatomical variability beyond what is usually achieved by standard analysis packages and avoids mutually referring to neighbouring gyri when defining gyral edges. We also provide grey matter thickness, grey matter volume, and white matter surface area information for each parcel. This dataset and corresponding measurements are useful in assessing the accuracy of equivalent parcels and metrics generated by image analysis tools and their impact on morphometric studies. Design Type(s) image creation and editing objective • protocol optimization objective • organism part comparison design Measurement Type(s) brain morphological measurement Technology Type(s) MRI Scanner Factor Type(s) age • sex • Laterality Sample Characteristic(s) Homo sapiens • superior frontal gyrus • supramarginal gyrus • cingulate gyrus Machine-accessible metadata file describing the reported data (ISA-Tab format)