Outer Membrane Vesicle-Host Cell Interactions

Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions. OMVs can transport a broad range...

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Bibliographic Details
Published in:Microbiology spectrum 2019-01, Vol.7 (1)
Main Authors: Cecil, Jessica D, Sirisaengtaksin, Natalie, O'Brien-Simpson, Neil M, Krachler, Anne Marie
Format: Article
Language:English
Subjects:
Bacterial Outer Membrane Proteins
Bacterial Outer Membrane Proteins - immunology
Bacterial Outer Membrane Proteins - metabolism
Biological Transport - physiology
Cell Membrane
Cell Membrane - metabolism
Gram-Negative Bacteria
Gram-Negative Bacteria - immunology
Gram-Negative Bacteria - metabolism
Humans
Lipopolysaccharides - immunology
Lipopolysaccharides - metabolism
Pathogenesis
Proteolipids
Proteolipids - immunology
Proteolipids - metabolism
Transport Vesicles
Transport Vesicles - metabolism
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Summary:Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and during infection and are now recognized to play crucial roles during host-microbe interactions. OMVs can transport a broad range of chemically diverse cargoes, including lipids and lipopolysaccharides, membrane-embedded and associated proteins and small molecules, peptidoglycan, and nucleic acids. Particularly, virulence factors such as adhesins and toxins are often enriched in OMVs. Here we discuss a variety of ways in which OMVs facilitate host-microbe interactions, including their contributions to biofilm formation, nutrient scavenging, and modulation of host cell function. We particularly examine recent findings regarding OMV-host cell interactions in the oral cavity and the gastrointestinal tract.
ISSN:2165-0497
2165-0497
DOI:10.1128/microbiolspec.psib-0001-2018