Low‑q Bicelles Are Mixed Micelles

Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of “isotropic” bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest...

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Bibliographic Details
Published in:The journal of physical chemistry letters 2018-08, Vol.9 (15), p.4469-4473
Main Authors: Caldwell, Tracy A, Baoukina, Svetlana, Brock, Ashton T, Oliver, Ryan C, Root, Kyle T, Krueger, Joanna K, Glover, Kerney Jebrell, Tieleman, D. Peter, Columbus, Linda
Format: Article
Language:English
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Summary:Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of “isotropic” bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest that bicelles with a q value below 1 deviate from the classic bicelle that contains lipids in the core and detergent in the rim. Thus not all isotropic bicelles are bilayer-like.
ISSN:1948-7185
1948-7185
DOI:10.1021/acs.jpclett.8b02079