Dosage Compensation of the X Chromosomes in Bovine Germline, Early Embryos, and Somatic Tissues

Abstract Dosage compensation of the mammalian X chromosome (X) was proposed by Susumu Ohno as a mechanism wherein the inactivation of one X in females would lead to doubling the expression of the other. This would resolve the dosage imbalance between eutherian females (XX) versus male (XY) and betwe...

Full description

Saved in:
Bibliographic Details
Published in:Genome biology and evolution 2019-01, Vol.11 (1), p.242-252
Main Authors: Duan, Jingyue (Ellie), Shi, Wei, Jue, Nathaniel K, Jiang, Zongliang, Kuo, Lynn, O’Neill, Rachel, Wolf, Eckhard, Dong, Hong, Zheng, Xinbao, Chen, Jingbo, Tian, Xiuchun (Cindy)
Format: Article
Language:English
Subjects:
Animals
Cattle
Dosage Compensation, Genetic
Embryo, Mammalian - metabolism
Female
Gene Expression
Male
Oocytes - metabolism
Original
Pseudoautosomal Regions
Up-Regulation
X Chromosome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Dosage compensation of the mammalian X chromosome (X) was proposed by Susumu Ohno as a mechanism wherein the inactivation of one X in females would lead to doubling the expression of the other. This would resolve the dosage imbalance between eutherian females (XX) versus male (XY) and between a single active X versus autosome pairs (A). Expression ratio of X- and A-linked genes has been relatively well studied in humans and mice, despite controversial results over the existence of upregulation of X-linked genes. Here we report the first comprehensive test of Ohno’s hypothesis in bovine preattachment embryos, germline, and somatic tissues. Overall an incomplete dosage compensation (0.5 
ISSN:1759-6653
1759-6653
DOI:10.1093/gbe/evy270