Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm

•Placental CpG methylation in relation to cognition at age 10 was evaluated.•Ten HPA axis-associated genes were associated with cognitive function.•The transcriptional regulator MECP2 was enriched within the ten HPA axis genes.•Placental CpG methylation in the context of fetal development is discuss...

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Bibliographic Details
Published in:Hormones and behavior 2018-05, Vol.101, p.29-35
Main Authors: Meakin, C.J., Martin, E.M., Santos, H.P., Mokrova, I., Kuban, K., O'Shea, T.M., Joseph, R.M., Smeester, L., Fry, R.C.
Format: Article
Language:English
Subjects:
CpG DNA methylation
Epigenetics
HPA axis
Placenta
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Summary:•Placental CpG methylation in relation to cognition at age 10 was evaluated.•Ten HPA axis-associated genes were associated with cognitive function.•The transcriptional regulator MECP2 was enriched within the ten HPA axis genes.•Placental CpG methylation in the context of fetal development is discussed.•This study relates to the developmental origins of health and disease hypothesis.
ISSN:0018-506X
1095-6867
1095-6867
DOI:10.1016/j.yhbeh.2018.02.007