Biological activities of Ficus carica latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers

Infection caused by high-risk human papillomaviruses (HPVs) are implicated in the aetiology of cervical cancer. Although current methods of treatment for cervical cancer can ablate lesions, preventing metastatic disseminations and excessive tissue injuries still remains a major concern. Hence, devel...

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Bibliographic Details
Published in:Scientific reports 2019-01, Vol.9 (1), p.1013-1013, Article 1013
Main Authors: Ghanbari, Arshia, Le Gresley, Adam, Naughton, Declan, Kuhnert, Nikolai, Sirbu, Diana, Ashrafi, G. Hossein
Format: Article
Language:English
Subjects:
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Cervical cancer
Cervix
Data processing
Ficus carica
Human papillomavirus
Humanities and Social Sciences
Latex
Lesions
Metastases
multidisciplinary
Natural products
Papillomaviridae
Science
Science (multidisciplinary)
Skin
Transformed cells
Tumor cell lines
Warts
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Summary:Infection caused by high-risk human papillomaviruses (HPVs) are implicated in the aetiology of cervical cancer. Although current methods of treatment for cervical cancer can ablate lesions, preventing metastatic disseminations and excessive tissue injuries still remains a major concern. Hence, development of a safer and more efficient treatment modality is of vital importance. Natural products from plants are one of the principal sources of precursors to lead compounds with direct pharmaceutical application across all disease classes. One of these plants is Ficus carica , whose fruit latex, when applied on HPV-induced skin warts, has shown potential as a possible cure for this virus related lesions. This study explores the in vitro biological activities of fig latex and elucidates its possible mechanisms of action on cervical cancer cell lines CaSki and HeLa positive for HPV type 16 and 18, respectively. Our data shows that fig latex inhibits properties that are associated with HPV-positive cervical cancer transformed cells such as rapid growth and invasion and substantially downregulated the expression of p16 and HPV onco-proteins E6, E7. These findings suggest Ficus carica latex has the potential to be used in the development of therapeutic modalities for the possible treatment, cure and prevention of HPV related cervical cancer.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-37665-6