Connexins and Integrins in Exosomes

Connexins and integrins, the two structurally and functionally distinct families of transmembrane proteins, have been shown to be inter-connected by various modes of cross-talk in cells, such as direct physical coupling via lateral contact, indirect physical coupling via actin and actin-binding prot...

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Bibliographic Details
Published in:Cancers 2019-01, Vol.11 (1), p.106
Main Authors: Shimaoka, Motomu, Kawamoto, Eiji, Gaowa, Arong, Okamoto, Takayuki, Park, Eun Jeong
Format: Article
Language:English
Subjects:
Actin
Cancer
Cardiomyocytes
Cell adhesion & migration
Cell cycle
Cell signaling
Connexins
Cytoplasm
Cytoskeleton
Exosomes
Extracellular matrix
Inflammation
Integrins
Ligands
Membrane proteins
Metastases
Nanoparticles
Physiology
Proteins
Review
Shear stress
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Summary:Connexins and integrins, the two structurally and functionally distinct families of transmembrane proteins, have been shown to be inter-connected by various modes of cross-talk in cells, such as direct physical coupling via lateral contact, indirect physical coupling via actin and actin-binding proteins, and functional coupling via signaling cascades. This connexin-integrin cross-talk exemplifies a biologically important collaboration between channels and adhesion receptors in cells. Exosomes are biological lipid-bilayer nanoparticles secreted from virtually all cells via endosomal pathways into the extracellular space, thereby mediating intercellular communications across a broad range of health and diseases, including cancer progression and metastasis, infection and inflammation, and metabolic deregulation. Connexins and integrins are embedded in the exosomal membranes and have emerged as critical regulators of intercellular communication. This concise review article will explain and discuss recent progress in better understanding the roles of connexins, integrins, and their cross-talk in cells and exosomes.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11010106