SMC5/6: Multifunctional Player in Replication

The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints...

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Bibliographic Details
Published in:Genes 2018-12, Vol.10 (1), p.7
Main Author: Palecek, Jan J
Format: Article
Language:English
Subjects:
Chromosomes
Cohesin
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA damage
Genomes
Mutation
Organisms
Prokaryotes
Proteins
Replication
Review
Ribosomal DNA
Roles
Telomerase
Yeast
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Summary:The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes10010007