High FOXM1 expression is a prognostic marker for poor clinical outcomes in prostate cancer

We aimed to investigate the expression of FOXM1 and to determine the relationships between FOXM1 expression and clinicopathologic characteristics in patients with PCa. Furthermore, we reconfirmed the prognostic impact of FOXM1 in different cohorts using already published data. Formalin-fixed, paraff...

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Bibliographic Details
Published in:Journal of Cancer 2019, Vol.10 (3), p.749-756
Main Authors: Kim, Mee Young, Jung, Ae Ryang, Kim, Ga Eun, Yang, Jonghyup, Ha, U-Syn, Hong, Sung-Hoo, Choi, Yeong Jin, Moon, Mi Hyoung, Kim, Sae Woong, Lee, Ji Youl, Park, Yong Hyun
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Language:English
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Summary:We aimed to investigate the expression of FOXM1 and to determine the relationships between FOXM1 expression and clinicopathologic characteristics in patients with PCa. Furthermore, we reconfirmed the prognostic impact of FOXM1 in different cohorts using already published data. Formalin-fixed, paraffin-embedded tissues were collected from patients with low- (n=17), intermediate- (n=36), and high-risk (n=29) disease, from patients with CRPC (n=2) and from patients with BPH (n=28). To analyze FOXM1 expression, we performed IHC analyses. Also, we analyzed gene expression data from cBioPortal to evaluate the associations between FOXM1 alteration and prognosis of PCa. FOXM1 expression measured using Allred score differed between patients with BPH, and low-, intermediate-, and high-risk PCa (0.3, 1.5, 4.8, and 6.2, respectively; p
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.28099