ZincBind—the database of zinc binding sites

Abstract Zinc is one of the most important biologically active metals. Ten per cent of the human genome is thought to encode a zinc binding protein and its uses encompass catalysis, structural stability, gene expression and immunity. At present, there is no specific resource devoted to identifying a...

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Bibliographic Details
Published in:Database : the journal of biological databases and curation 2019-01, Vol.2019
Main Authors: Ireland, Sam M, Martin, Andrew C R
Format: Article
Language:English
Subjects:
Binding sites
Biological activity
Catalysis
Gene expression
Genomes
Heavy metals
Original
Proteins
Zinc
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Summary:Abstract Zinc is one of the most important biologically active metals. Ten per cent of the human genome is thought to encode a zinc binding protein and its uses encompass catalysis, structural stability, gene expression and immunity. At present, there is no specific resource devoted to identifying and presenting all currently known zinc binding sites. Here we present ZincBind, a database of zinc binding sites and its web front-end. Using the structural data in the Protein Data Bank, ZincBind identifies every instance of zinc binding to a protein, identifies its binding site and clusters sites based on 90% sequence identity. There are currently 24 992 binding sites, clustered into 7489 unique sites. The data are available over the web where they can be browsed and downloaded, and via a REST API. ZincBind is regularly updated and will continue to be updated with new data and features.
ISSN:1758-0463
1758-0463
DOI:10.1093/database/baz006