Biomaterial-Derived Calcium Carbonate Nanoparticles for Enteric Drug Delivery

Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO3) nanoparticles were used to develop enteric drug delivery system in the form of tablets. CaCO3 nanoparticles were...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nanomaterials 2016-01, Vol.2016 (2016), p.1-8
Main Authors: Rangari, Vijaya K., Jeelani, Shaik, Vig, Madan, King, Howard, Samuel, Temesgen, Render, Diane, Babu, Ramapuram Jayachandra
Format: Article
Language:English
Subjects:
Binders
Calcium
Calcium carbonate
Colon
Controlled release
Drug delivery systems
Drugs
Ethanol
Glycerol
Nanomaterials
Nanoparticles
Pharmaceuticals
Rabbits
Stomach
Studies
Tablets
Transmission electron microscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Oral drug delivery systems provide the most convenient, noninvasive, readily acceptable alternatives to parenteral systems. In the current work, eggshell-derived calcium carbonate (CaCO3) nanoparticles were used to develop enteric drug delivery system in the form of tablets. CaCO3 nanoparticles were manufactured using top-down ball-milling method and characterized by X-ray diffractometry (XRD) and transmission electron microscopy (TEM) and loaded with 5-fluorouracil as a model drug. Tablets with varying CaCO3 core and binder compositions were fabricated and coated with Eudragit S100 or Eudragit L100. Suitability for enteric delivery of the tablets was tested by oral administration to rabbits and radiography. Radiograph images showed that the tablet remained in the stomach of the rabbit for up to 3 hours. Further modifications of these biomaterial-derived nanoparticles and the coatings will enable manufacturing of stable formulations for slow or controlled release of pharmaceuticals for enteric delivery.
ISSN:1687-4110
1687-4129
DOI:10.1155/2016/3170248