May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolis...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2019-02, Vol.39 (2), p.367-370
Main Authors: Borlongan, Cesar V, Nguyen, Hung, Lippert, Trenton, Russo, Eleonora, Tuazon, Julian, Xu, Kaya, Lee, Jea-Young, Sanberg, Paul R, Kaneko, Yuji, Napoli, Eleonora
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Brain - pathology
Disease Models, Animal
Humans
Mitochondria - metabolism
Mitochondria - pathology
Mitochondria - transplantation
Rats
Rats, Sprague-Dawley
Stem Cells - metabolism
Stem Cells - pathology
Stroke - metabolism
Stroke - pathology
Stroke - therapy
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Summary:Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells’ regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.
ISSN:0271-678X
1559-7016
DOI:10.1177/0271678X18811277