Potential Prognostic Factors of Downstaging Following Preoperative Chemoradiation for High Rectal Cancer

Treatment for high rectal cancers, particularly the value of preoperative treatment, is controversial. In our previous study, downstaging by preoperative chemoradiation resulted in improved outcomes. The aim of the present study was to identify prognostic factors to predict which patients will achie...

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Bibliographic Details
Published in:In vivo (Athens) 2018-11, Vol.32 (6), p.1481-1484
Main Authors: Treder, Maxi, Vogelsang, Rasmus Peuliche, Janssen, Stefan, Schild, Steven E, Holländer, Niels Henrik, Rades, Dirk
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Chemoradiotherapy
Disease-Free Survival
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Staging
Prognosis
Rectal Neoplasms - drug therapy
Rectal Neoplasms - pathology
Rectal Neoplasms - radiotherapy
Treatment Outcome
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Summary:Treatment for high rectal cancers, particularly the value of preoperative treatment, is controversial. In our previous study, downstaging by preoperative chemoradiation resulted in improved outcomes. The aim of the present study was to identify prognostic factors to predict which patients will achieve downstaging and may benefit from preoperative treatment. In 54 patients with locally advanced non-metastatic high rectal cancer, 8 factors were evaluated for downstaging by preoperative chemoradiation including age, gender, carcinoembryonic antigen level, performance status, T-/N-category, UICC-stage (Union for International Cancer Control) and histological grade. Downstaging was defined as decrease by at least one UICC-stage. Downstaging was achieved in 36 patients (67%). Patients at UICC-stage III showed a trend for downstaging. The majority of patients with UICC-stage III tumors were downstaged and appear to benefit from preoperative chemoradiation. In general, the potential value of preoperative treatment for high rectal cancers needs further investigation.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.11403