Correlation Between Dosimetric Parameters and Acute Dermatitis of Post-operative Radiotherapy in Breast Cancer Patients

To examine the correlation between dosimetric parameters and acute radiation dermatitis in early breast cancer patients subjected to post-operative radiotherapy. The data of 84 patients treated with post-operative radiotherapy were analyzed. The total prescribed dose was 50 Gy in 25 fractions over 5...

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Bibliographic Details
Published in:In vivo (Athens) 2018-11, Vol.32 (6), p.1499-1504
Main Authors: Takenaka, Tadashi, Yamazaki, Hideya, Suzuki, Gen, Aibe, Norihiro, Masui, Koji, Shimizu, Daisuke, Nishimura, Takeshi, Nakashima, Akihiro, Ogata, Toshiyuki, Matsushita, Keiichiro, Yoshida, Ken, Yamada, Kei
Format: Article
Language:English
Subjects:
Adult
Aged
Breast - pathology
Breast - radiation effects
Breast - surgery
Breast Neoplasms - complications
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Dermatitis - etiology
Dermatitis - pathology
Female
Humans
Middle Aged
Postoperative Period
Radiation Dosage
Radiotherapy Dosage
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Summary:To examine the correlation between dosimetric parameters and acute radiation dermatitis in early breast cancer patients subjected to post-operative radiotherapy. The data of 84 patients treated with post-operative radiotherapy were analyzed. The total prescribed dose was 50 Gy in 25 fractions over 5 weeks. Radiation dermatitis was assessed according to Common Terminology Criteria for Adverse Events v4.0. We set organ at risk whole body (from neck to abdomen examined by CT images) also as surrogate skin volume (3 mm thickness). A total of 28 patients showed radiation dermatitis grade equal or higher than 2 at the 50 Gy time point. These 28 patients were compared to 56 matched pair patients with grade 0-1 radiation dermatitis during the same treatment period. The mean of V5-20 and V40 in patient's whole volume and V40-50 in skin volume were significantly higher in patients who presented with acute radiation dermatitis Grades ≥2 than in the other patients who did not. The statistically most significant difference was observed for V40 for skin volume and V5 for patient whole volume. Rate of acute radiation dermatitis grade ≥2 was significantly higher for patients with V5 (whole body) >1,360 cm than those with V5 (whole body) 45 cm compared with those with V40 (skin volume)
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.11406