miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis

Aortic valve stenosis is the most common cause of morbidity and mortality in valvular heart disease in aged people. Both microRNA (miRNA) and mRNA are potential targets for the diagnosis and therapeutic intervention of myocardial ischemia induced by calcified aortic valve stenosis (CAVS), with uncle...

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Published in:Aging (Albany, NY.) NY.), 2019-01, Vol.11 (2), p.448-466
Main Authors: Duan, Chenyang, Cao, Zhezhe, Tang, Fuqin, Jian, Zhao, Liang, Chunshui, Liu, Hong, Xiao, Yingbin, Liu, Liangming, Ma, Ruiyan
Format: Article
Language:English
Subjects:
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - metabolism
Aortic Valve Stenosis - pathology
Calcinosis - pathology
Gene Expression Regulation
Humans
Male
MicroRNAs - genetics
MicroRNAs - metabolism
Mitochondria - metabolism
Myocardial Ischemia - etiology
Myocardial Ischemia - metabolism
Reactive Oxygen Species
Research Paper
RNA, Messenger - genetics
RNA, Messenger - metabolism
Transcriptome
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Summary:Aortic valve stenosis is the most common cause of morbidity and mortality in valvular heart disease in aged people. Both microRNA (miRNA) and mRNA are potential targets for the diagnosis and therapeutic intervention of myocardial ischemia induced by calcified aortic valve stenosis (CAVS), with unclear mechanisms. Here, 3 gene expression profiles of 47 male participants were applied to generate shared differentially expressed genes (DEGs) with significant major biological functions. Moreover, 20 hub genes were generated by a Weighted Genes Co-Expression Network Analysis (WGCNA) and were cross-linked to miRNA based on miRanda/miRwalk2 databases. Integrated miRNA/mRNA analysis identified several novel miRNAs and targeted genes as diagnostic/prognostic biomarkers or therapeutic targets in CAVS patients. In addition, the clinical data suggested that myocardial hypertrophy and myocardial ischemia in CAVS patients are likely associated with hub genes and the upstream regulatory miRNAs. Together, our data provide evidence that miRNAs and their targeted genes play an important role in the pathogenesis of myocardial hypertrophy and ischemia in patients with CAVS.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101751