Strong, weak and neuron type dependent lateral inhibition in the olfactory bulb

In many sensory systems, different sensory features are transmitted in parallel by several different types of output neurons. In the mouse olfactory bulb, there are only two output neuron types, the mitral and tufted cells (M/T), which receive similar odor inputs, but they are believed to transmit d...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.1602-1602, Article 1602
Main Authors: Shmuel, Ronit, Secundo, Lavi, Haddad, Rafi
Format: Article
Language:English
Subjects:
631/378/116/2395
631/378/2624/1703
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Electrophysiology
Genetics
Humanities and Social Sciences
Information processing
Inhibition
multidisciplinary
Neurons
Odor
Odors
Olfactory bulb
Optics
Respiration
Science
Science (multidisciplinary)
Sensory evaluation
Sensory systems
Somatosensory cortex
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Summary:In many sensory systems, different sensory features are transmitted in parallel by several different types of output neurons. In the mouse olfactory bulb, there are only two output neuron types, the mitral and tufted cells (M/T), which receive similar odor inputs, but they are believed to transmit different odor characteristics. How these two neuron types deliver different odor information is unclear. Here, by combining electrophysiology and optogenetics, it is shown that distinct inhibitory networks modulate M/T cell responses differently. Overall strong lateral inhibition was scarce, with most neurons receiving lateral inhibition from a handful of unorganized surrounding glomeruli (~5% on average). However, there was a considerable variability between different neuron types in the strength and frequency of lateral inhibition. Strong lateral inhibition was mostly found in neurons locked to the first half of the respiration cycle. In contrast, weak inhibition arriving from many surrounding glomeruli was relatively more common in neurons locked to the late phase of the respiration cycle. Proximal neurons could receive different levels of inhibition. These results suggest that there is considerable diversity in the way M/T cells process odors so that even neurons that receive the same odor input transmit different odor information to the cortex.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-38151-9