3D-printed β-TCP bone tissue engineering scaffolds: Effects of chemistry on in vivo biological properties in a rabbit tibia model

In this study, the effects of 3D-printed SiO2 and ZnO-doped tricalcium phosphate (TCP) scaffolds with interconnected pores were evaluated on the in vivo bone formation and healing properties of a rabbit tibial defect model. Pure and doped TCP scaffolds were fabricated by a ceramic powder-based 3D pr...

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Bibliographic Details
Published in:Journal of materials research 2018, Vol.33 (14), p.1939-1947
Main Authors: Nandi, Samit Kumar, Fielding, Gary, Banerjee, Dishary, Bandyopadhyay, Amit, Bose, Susmita
Format: Article
Language:English
Subjects:
3-D printers
Angiogenesis
Animals
Applied and Technical Physics
Biocompatibility
Biological properties
Biomaterials
Biomedical materials
Bones
Calcium phosphates
Ceramic powders
Defects
Dopants
Ethanol
Healing
Hydroxyapatite
In vivo methods and tests
Inorganic Chemistry
Invited Article
Materials Engineering
Materials research
Materials Science
Mechanical properties
Nanotechnology
Organic chemistry
Orthopedics
Photomicrographs
Pore size
Printing
Rabbits
Regeneration (physiology)
Scaffolds
Silicon dioxide
Studies
Surgical implants
Sutures
Three dimensional printing
Tibia
Tissue engineering
Transplants & implants
Zinc oxide
Zinc oxides
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Summary:In this study, the effects of 3D-printed SiO2 and ZnO-doped tricalcium phosphate (TCP) scaffolds with interconnected pores were evaluated on the in vivo bone formation and healing properties of a rabbit tibial defect model. Pure and doped TCP scaffolds were fabricated by a ceramic powder-based 3D printing technique and implanted into critical sized rabbit tibial defects for up to 4 months. In vivo bone regeneration was evaluated using chronological radiological examination, histological evaluations, SEM micrographs, and fluorochrome labeling studies. Radiograph results showed that Si/Zn-doped samples had slower degradation kinetics than the pure TCP samples. 3D printing of TCP scaffolds improved bone formation. The addition of dopants in the TCP scaffolds improved osteogenic capabilities when compared to the pure scaffolds. In summary, our findings indicate that the addition of dopants to the TCP scaffolds enhanced bone formation and in turn leading to accelerated healing.
ISSN:0884-2914
2044-5326
DOI:10.1557/jmr.2018.233