Design, synthesis and in vitro cytotoxicity studies of novel β-carbolinium bromides

[Display omitted] A series of novel β-carbolinium bromides has been synthesized from easily accessible β-carbolines and 1-aryl-2-bromoethanones. The newly synthesized compounds were evaluated for their in vitro anticancer activity. Among the synthesized derivatives, compounds 16l, 16o and 16s exhibi...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2017-03, Vol.27 (6), p.1379-1384
Main Authors: Venkataramana Reddy, P.O., Mishra, Shriprada, Tantak, Mukund P., Nikhil, Kumar, Sadana, Rachna, Shah, Kavita, Kumar, Dalip
Format: Article
Language:English
Subjects:
Apoptosis
Bromides - chemical synthesis
Bromides - chemistry
Bromides - pharmacology
Carbolines - chemical synthesis
Carbolines - chemistry
Carbolines - pharmacology
Cell Line, Tumor
Drug Design
Humans
In vitro cytotoxicity
Male
Microwave
Prostatic Neoplasms - pathology
β-Carbolinium bromides
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Summary:[Display omitted] A series of novel β-carbolinium bromides has been synthesized from easily accessible β-carbolines and 1-aryl-2-bromoethanones. The newly synthesized compounds were evaluated for their in vitro anticancer activity. Among the synthesized derivatives, compounds 16l, 16o and 16s exhibited potent anticancer activity with IC50 values of
ISSN:0960-894X
1464-3405
1464-3405
DOI:10.1016/j.bmcl.2017.02.010