Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0–1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorp...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2019-02, Vol.116 (6), p.1968-1973
Main Authors: Sun, Yue, Ding, Feng, Zhou, Zhixuan, Li, Chonglu, Pu, Maoping, Xu, Yuling, Zhan, Yibei, Lu, Xiaoju, Li, Haibing, Yang, Guangfu, Sun, Yao, Stang, Peter J.
Format: Article
Language:English
Subjects:
Animals
Cancer
Diagnosis
Emission analysis
Fluorescence
Fluorescent indicators
Fluoroscopic imaging
In vivo methods and tests
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Near infrared radiation
Neoplasms - diagnostic imaging
Neoplasms - therapy
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - therapy
Organic chemistry
Organometallic compounds
Penetration depth
Permeability
Photons
Physical Sciences
Polyethylene glycol
Precision medicine
Side effects
Signal quality
Signal-To-Noise Ratio
Theranostic Nanomedicine - methods
Tumors
Wavelengths
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Summary:Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0–1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoylsn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Our studies show that 1 accurately diagnoses cancer with high resolution and selectively delivers the Pt(II) metallacycle to tumor regions via an enhanced permeability and retention effect. In vivo studies reveal that 1 efficiently inhibits the growth of tumor with minimal side effects. At the same time, improved fluorescent imaging quality and signal-to-noise ratios are shown due to the long emission wavelengths. These studies demonstrate that 1 is a potential theranostic platform for tumor diagnosis and treatment in the NIR-II region.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1817021116