Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0–1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorp...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2019-02, Vol.116 (6), p.1968-1973
Main Authors: Sun, Yue, Ding, Feng, Zhou, Zhixuan, Li, Chonglu, Pu, Maoping, Xu, Yuling, Zhan, Yibei, Lu, Xiaoju, Li, Haibing, Yang, Guangfu, Sun, Yao, Stang, Peter J.
Format: Article
Language:English
Subjects:
Animals
Cancer
Diagnosis
Emission analysis
Fluorescence
Fluorescent indicators
Fluoroscopic imaging
In vivo methods and tests
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Near infrared radiation
Neoplasms - diagnostic imaging
Neoplasms - therapy
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - therapy
Organic chemistry
Organometallic compounds
Penetration depth
Permeability
Photons
Physical Sciences
Polyethylene glycol
Precision medicine
Side effects
Signal quality
Signal-To-Noise Ratio
Theranostic Nanomedicine - methods
Tumors
Wavelengths
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cited_by cdi_FETCH-LOGICAL-c509t-327a383d4f374755cbdc989015385281643892e220087b1ec5894b9674554493
cites cdi_FETCH-LOGICAL-c509t-327a383d4f374755cbdc989015385281643892e220087b1ec5894b9674554493
container_end_page 1973
container_issue 6
container_start_page 1968
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 116
creator Sun, Yue
Ding, Feng
Zhou, Zhixuan
Li, Chonglu
Pu, Maoping
Xu, Yuling
Zhan, Yibei
Lu, Xiaoju
Li, Haibing
Yang, Guangfu
Sun, Yao
Stang, Peter J.
description Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0–1.7 μm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoylsn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Our studies show that 1 accurately diagnoses cancer with high resolution and selectively delivers the Pt(II) metallacycle to tumor regions via an enhanced permeability and retention effect. In vivo studies reveal that 1 efficiently inhibits the growth of tumor with minimal side effects. At the same time, improved fluorescent imaging quality and signal-to-noise ratios are shown due to the long emission wavelengths. These studies demonstrate that 1 is a potential theranostic platform for tumor diagnosis and treatment in the NIR-II region.
doi_str_mv 10.1073/pnas.1817021116
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subjects Animals
Cancer
Diagnosis
Emission analysis
Fluorescence
Fluorescent indicators
Fluoroscopic imaging
In vivo methods and tests
Magnetic Resonance Imaging
Mice
Mice, Inbred C57BL
Near infrared radiation
Neoplasms - diagnostic imaging
Neoplasms - therapy
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - therapy
Organic chemistry
Organometallic compounds
Penetration depth
Permeability
Photons
Physical Sciences
Polyethylene glycol
Precision medicine
Side effects
Signal quality
Signal-To-Noise Ratio
Theranostic Nanomedicine - methods
Tumors
Wavelengths
title Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy
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