Enhancement of immune maturation in suckling rats by leptin and adiponectin supplementation

• Published in: Scientific reports 2019-02, Vol.9 (1), p.1786-1786, Article 1786
• Main Authors: Grases-Pintó, Blanca, Abril-Gil, Mar, Castell, Margarida, Pérez-Cano, Francisco J., Franch, Àngels
• Format: Article
• Language: English
• Subjects: 13/106; 13/21; 13/31; 631/250/1619; 692/308/3187; 82/1; Adiponectin; Breast milk; CD4 antigen; CD8 antigen; Cytokines; Dietary supplements; Humanities and Social Sciences; Immune response; Immune system; Immunoglobulin G; Immunoglobulin M; Immunomodulation; Leptin; Leptina; Llet materna; Lymphocytes; Lymphocytes T; multidisciplinary; Neonates; Rodents; Science; Science (multidisciplinary); Sistema immunològic; Spleen; Splenocytes; Suckling behavior
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-38418-1

Leptin and adiponectin, adipokines present in breast milk, have shown immunomodulatory properties. The current study aimed to ascertain whether a nutritional supplementation with leptin or adiponectin in neonatal rats was able to influence the maturation of the systemic immune response in early life. To achieve this, suckling Wistar rats were supplemented with either leptin (0.7 μg/kg/day) or adiponectin (35 μg/kg/day) during the whole suckling period. Plasmatic immunoglobulins were quantified, and spleen lymphocyte composition and their ability to proliferate and release cytokines were evaluated during (day 14) and at the end (day 21) of the suckling period. Rats fed with either adipokine showed higher plasma IgM and IgG1 concentrations and adiponectin supplementation also increased IgG2a at both studied days (P