Endocan as a marker of microvascular inflammation in kidney transplant recipients

Endocan is a water-soluble proteoglycan exclusively secreted by vascular endothelium. Endocan levels may be elevated in kidney transplant recipients experiencing antibody-mediated rejection (ABMR), which is characterized by vascular inflammation in transplanted kidney. We evaluated the clinical rele...

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Published in:Scientific reports 2019-02, Vol.9 (1), p.1854-1854, Article 1854
Main Authors: Lee, Yu Ho, Kim, Se-Yun, Moon, Haena, Seo, Jung-Woo, Kim, Dong-Jin, Park, Seon Hwa, Kim, Yang-Gyun, Moon, Ju-Young, Kim, Jin Sug, Jeong, Kyung-Hwan, Lim, Sung-Jig, Kim, Chan-Duck, Park, Jae Berm, Chung, Byung Ha, Kim, Yeong Hoon, Yang, Jaeseok, Yang, Hyung-In, Kim, Kyoung Soo, Lee, Sang-Ho
Format: Article
Language:English
Subjects:
13/51
14/19
692/4022/1585
692/53/2423
Endothelium
Graft rejection
Humanities and Social Sciences
Inflammation
Kidney transplantation
Kidney transplants
Lymphocytes T
Microvasculature
multidisciplinary
Nephropathy
Plasma
Pyelonephritis
Science
Science (multidisciplinary)
Transplants & implants
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Summary:Endocan is a water-soluble proteoglycan exclusively secreted by vascular endothelium. Endocan levels may be elevated in kidney transplant recipients experiencing antibody-mediated rejection (ABMR), which is characterized by vascular inflammation in transplanted kidney. We evaluated the clinical relevance of endocan as markers of microvascular inflammation in patients who underwent kidney transplantation. Plasma and urinary endocan levels were measured in 203 kidney transplant recipients and were compared across different etiologies of allograft dysfunction and various pathologic scores. Both plasma and urinary endocan levels were significantly higher in patients with acute ABMR than those in patients with normal pathology, acute tubular necrosis (ATN), acute pyelonephritis, BK virus associated nephropathy (BKVN), and T-cell mediated rejection (TCMR). Patients with chronic active ABMR also exhibited significantly higher plasma and urinary endocan levels than patients with long-term graft survival. Scores of glomerulitis and peritubular capillaritis, which are typical features of microvascular inflammation, were significantly elevated in patients with higher plasma and/or urinary endocan levels. Furthermore, plasma and urinary endocan levels could effectively discriminate ABMR from ATN, BKVN, and TCMR. Finally, patients exhibiting high urinary and plasma endocan levels in acute ABMR group showed significantly worse renal survival. Altogether, plasma and urinary endocan levels may serve as potential markers of microvascular inflammation in kidney transplant recipients.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-37975-9