Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer

Currently, despite the advances in individualized treatment, breast cancer still remains the deadliest form of cancer in women. Diagnostic, prognostic, and therapy-predictive methods are mainly based on the evaluation of tumor tissue samples and are aimed to improve the overall therapeutic level. Th...

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Bibliographic Details
Published in:Technology in Cancer Research & Treatment 2019, Vol.18, p.1533033818821421
Main Authors: Meng, Yiming, Sun, Jing, Wang, Xiaonan, Hu, Tingting, Ma, Yushu, Kong, Cuicui, Piao, Haozhe, Yu, Tao, Zhang, Guirong
Format: Article
Language:English
Subjects:
Biomarkers
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - metabolism
Exosomes - metabolism
Female
Humans
MicroRNAs
Prognosis
Review
Targeted cancer therapy
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Summary:Currently, despite the advances in individualized treatment, breast cancer still remains the deadliest form of cancer in women. Diagnostic, prognostic, and therapy-predictive methods are mainly based on the evaluation of tumor tissue samples and are aimed to improve the overall therapeutic level. Therefore, the exploration of a series of circulating biomarkers, which serve as the information source of tumors and could be obtained by peripheral blood samples, represents a high field of interest. Apart from classical biomarkers, exosomes, which are nanovesicles, are emerging as an accessible and efficient source of cell information. The purpose of this review is to summarize the peculiarities of the presently available breast cancer exosomal biomarkers; the review also provides the prediction of a multitude of potential target genes of exosomal microRNAs using 4 databases.
ISSN:1533-0346
1533-0338
1533-0338
DOI:10.1177/1533033818821421