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Adverse childhood experiences: Basics for the paediatrician
Abstract In 1998, the Centers for Disease Control and Prevention Adverse Childhood Experiences study established the profound effects of early childhood adversity on life course health. The burden of cumulative adversities can affect gene expression, immune system development and condition stress re...
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| Published in: | Paediatrics & child health 2019-02, Vol.24 (1), p.30-37 |
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| creator | Jacob, Gabriella van den Heuvel, Meta Jama, Nimo Moore, Aideen M Ford-Jones, Lee Wong, Peter D |
| description | Abstract
In 1998, the Centers for Disease Control and Prevention Adverse Childhood Experiences study established the profound effects of early childhood adversity on life course health. The burden of cumulative adversities can affect gene expression, immune system development and condition stress response. A scientific framework provides explanation for numerous childhood and adult health problems and high-risk behaviours that originate in early life. In our review, we discuss adverse childhood experiences, toxic stress, the neurobiological basis and multigenerational and epigenetic transmission of trauma and recognized health implications. Further, we outline building resilience, screening in the clinical setting, primary care interventions, applying trauma-informed care and future directions. We foresee that enhancing knowledge of the far-reaching effects of adverse childhood events will facilitate mitigation of toxic stress, promote child and family resilience and optimize life course health trajectories. |
| doi_str_mv | 10.1093/pch/pxy043 |
| format | article |
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In 1998, the Centers for Disease Control and Prevention Adverse Childhood Experiences study established the profound effects of early childhood adversity on life course health. The burden of cumulative adversities can affect gene expression, immune system development and condition stress response. A scientific framework provides explanation for numerous childhood and adult health problems and high-risk behaviours that originate in early life. In our review, we discuss adverse childhood experiences, toxic stress, the neurobiological basis and multigenerational and epigenetic transmission of trauma and recognized health implications. Further, we outline building resilience, screening in the clinical setting, primary care interventions, applying trauma-informed care and future directions. We foresee that enhancing knowledge of the far-reaching effects of adverse childhood events will facilitate mitigation of toxic stress, promote child and family resilience and optimize life course health trajectories.</description><identifier>ISSN: 1205-7088</identifier><identifier>EISSN: 1918-1485</identifier><identifier>DOI: 10.1093/pch/pxy043</identifier><identifier>PMID: 30792598</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adverse childhood experiences ; Child development ; Childhood ; Children ; Children & youth ; Childrens health ; Diseases ; Epigenetic inheritance ; Family relations ; Gene expression ; Genes ; Immune system ; Paediatric Progress: How Should It Change Your Practice? ; Pediatrics ; Personal experiences ; Physicians ; Setting (Literature) ; Stress ; Trauma</subject><ispartof>Paediatrics & child health, 2019-02, Vol.24 (1), p.30-37</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2018</rights><rights>COPYRIGHT 2019 Oxford University Press</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-4e38177ea6d3f3c49f233c9101b51b336a101e309ce27ae4eff5b6d7f2b54ca53</citedby><cites>FETCH-LOGICAL-c475t-4e38177ea6d3f3c49f233c9101b51b336a101e309ce27ae4eff5b6d7f2b54ca53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376298/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376298/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30792598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jacob, Gabriella</creatorcontrib><creatorcontrib>van den Heuvel, Meta</creatorcontrib><creatorcontrib>Jama, Nimo</creatorcontrib><creatorcontrib>Moore, Aideen M</creatorcontrib><creatorcontrib>Ford-Jones, Lee</creatorcontrib><creatorcontrib>Wong, Peter D</creatorcontrib><title>Adverse childhood experiences: Basics for the paediatrician</title><title>Paediatrics & child health</title><addtitle>Paediatr Child Health</addtitle><description>Abstract
In 1998, the Centers for Disease Control and Prevention Adverse Childhood Experiences study established the profound effects of early childhood adversity on life course health. The burden of cumulative adversities can affect gene expression, immune system development and condition stress response. A scientific framework provides explanation for numerous childhood and adult health problems and high-risk behaviours that originate in early life. In our review, we discuss adverse childhood experiences, toxic stress, the neurobiological basis and multigenerational and epigenetic transmission of trauma and recognized health implications. Further, we outline building resilience, screening in the clinical setting, primary care interventions, applying trauma-informed care and future directions. We foresee that enhancing knowledge of the far-reaching effects of adverse childhood events will facilitate mitigation of toxic stress, promote child and family resilience and optimize life course health trajectories.</description><subject>Adverse childhood experiences</subject><subject>Child development</subject><subject>Childhood</subject><subject>Children</subject><subject>Children & youth</subject><subject>Childrens health</subject><subject>Diseases</subject><subject>Epigenetic inheritance</subject><subject>Family relations</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Immune system</subject><subject>Paediatric Progress: How Should It Change Your Practice?</subject><subject>Pediatrics</subject><subject>Personal experiences</subject><subject>Physicians</subject><subject>Setting (Literature)</subject><subject>Stress</subject><subject>Trauma</subject><issn>1205-7088</issn><issn>1918-1485</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kVtrFjEQhoMotn564w-QBRFE2DbnQwXhs3iCgjd6HbLZSTdlv82a7Jb23xvZWtQLycUMmWfeyeRF6DnBJwQbdjr74XS-ucWcPUDHxBDdEq7Fw5pTLFqFtT5CT0q5wpgTjeljdMSwMlQYfYze7vtryAUaP8SxH1LqG7iZIUeYPJSz5r0r0ZcmpNwsAzSzgz66JUcf3fQUPQpuLPDsLu7Q948fvp1_bi--fvpyvr9oPVdiaTkwTZQCJ3sWmOcmUMa8IZh0gnSMSVdTYNh4oMoBhxBEJ3sVaCe4d4Lt0LtNd167A_QepiW70c45Hly-tclF-3dlioO9TNdWMiWp0VXg9Z1ATj9WKIs9xOJhHN0EaS2WEi2EZLJ-5g69_Ae9Smue6nqWMowlN5jzSp1s1KUbwcYppDrX19PDIfo0QYj1fi-JEIwZqmrDm63B51RKhnD_eoLtLxNtNdFuJlb4xZ_73qO_XavAqw1I6_w_oZ8seaUl</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Jacob, Gabriella</creator><creator>van den Heuvel, Meta</creator><creator>Jama, Nimo</creator><creator>Moore, Aideen M</creator><creator>Ford-Jones, Lee</creator><creator>Wong, Peter D</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FQ</scope><scope>8FV</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ASE</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K6X</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190201</creationdate><title>Adverse childhood experiences: Basics for the paediatrician</title><author>Jacob, Gabriella ; van den Heuvel, Meta ; Jama, Nimo ; Moore, Aideen M ; Ford-Jones, Lee ; Wong, Peter D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-4e38177ea6d3f3c49f233c9101b51b336a101e309ce27ae4eff5b6d7f2b54ca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adverse childhood experiences</topic><topic>Child development</topic><topic>Childhood</topic><topic>Children</topic><topic>Children & youth</topic><topic>Childrens health</topic><topic>Diseases</topic><topic>Epigenetic inheritance</topic><topic>Family relations</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Immune system</topic><topic>Paediatric Progress: How Should It Change Your Practice?</topic><topic>Pediatrics</topic><topic>Personal experiences</topic><topic>Physicians</topic><topic>Setting (Literature)</topic><topic>Stress</topic><topic>Trauma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jacob, Gabriella</creatorcontrib><creatorcontrib>van den Heuvel, Meta</creatorcontrib><creatorcontrib>Jama, Nimo</creatorcontrib><creatorcontrib>Moore, Aideen M</creatorcontrib><creatorcontrib>Ford-Jones, Lee</creatorcontrib><creatorcontrib>Wong, Peter D</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Canadian Business & Current Affairs Database</collection><collection>Canadian Business & Current Affairs Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>British Nursing Index</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Paediatrics & child health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jacob, Gabriella</au><au>van den Heuvel, Meta</au><au>Jama, Nimo</au><au>Moore, Aideen M</au><au>Ford-Jones, Lee</au><au>Wong, Peter D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse childhood experiences: Basics for the paediatrician</atitle><jtitle>Paediatrics & child health</jtitle><addtitle>Paediatr Child Health</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>24</volume><issue>1</issue><spage>30</spage><epage>37</epage><pages>30-37</pages><issn>1205-7088</issn><eissn>1918-1485</eissn><abstract>Abstract
In 1998, the Centers for Disease Control and Prevention Adverse Childhood Experiences study established the profound effects of early childhood adversity on life course health. The burden of cumulative adversities can affect gene expression, immune system development and condition stress response. A scientific framework provides explanation for numerous childhood and adult health problems and high-risk behaviours that originate in early life. In our review, we discuss adverse childhood experiences, toxic stress, the neurobiological basis and multigenerational and epigenetic transmission of trauma and recognized health implications. Further, we outline building resilience, screening in the clinical setting, primary care interventions, applying trauma-informed care and future directions. We foresee that enhancing knowledge of the far-reaching effects of adverse childhood events will facilitate mitigation of toxic stress, promote child and family resilience and optimize life course health trajectories.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>30792598</pmid><doi>10.1093/pch/pxy043</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Online; PubMed Central |
| subjects | Adverse childhood experiences Child development Childhood Children Children & youth Childrens health Diseases Epigenetic inheritance Family relations Gene expression Genes Immune system Paediatric Progress: How Should It Change Your Practice? Pediatrics Personal experiences Physicians Setting (Literature) Stress Trauma |
| title | Adverse childhood experiences: Basics for the paediatrician |
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