Photoacoustic oximetry imaging performance evaluation using dynamic blood flow phantoms with tunable oxygen saturation

Multispectral photoacoustic oximetry imaging (MPOI) is an emerging hybrid modality that enables the spatial mapping of blood oxygen saturation (SO ) to depths of several centimeters. To facilitate MPOI device development and clinical translation, well-validated performance test methods and improved...

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Bibliographic Details
Published in:Biomedical optics express 2019-02, Vol.10 (2), p.449-464
Main Authors: Vogt, William C, Zhou, Xuewen, Andriani, Rudy, Wear, Keith A, Pfefer, T Joshua, Garra, Brian S
Format: Article
Language:English
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Summary:Multispectral photoacoustic oximetry imaging (MPOI) is an emerging hybrid modality that enables the spatial mapping of blood oxygen saturation (SO ) to depths of several centimeters. To facilitate MPOI device development and clinical translation, well-validated performance test methods and improved quantitative understanding of physical processes and best practices are needed. We developed a breast-mimicking blood flow phantom with tunable SO and used this phantom to evaluate a custom MPOI system. Results provide quantitative evaluation of the impact of phantom medium properties (Intralipid versus polyvinyl chloride plastisol) and device design parameters (different transducers) on SO measurement accuracy, especially depth-dependent performance degradation due to fluence artifacts. This approach may guide development of standardized test methods for evaluating MPOI devices.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.10.000449