Asymmetrical and Isolated Hypoglossal Nerve Palsy Accompanied by a New Subset of Anti-ganglioside Antibodies in a Patient with Diffuse Large B Cell Lymphoma

Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside an...

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Bibliographic Details
Published in:Internal Medicine 2019/01/15, Vol.58(2), pp.283-286
Main Authors: Ohta, Yasuyuki, Kawahara, Yuko, Tadokoro, Koh, Sato, Kota, Sasaki, Ryo, Takahashi, Yoshiaki, Takemoto, Mami, Hishikawa, Nozomi, Yamashita, Toru, Asano, Takeru, Inomata, Tomoko, Abe, Koji
Format: Article
Language:English
Subjects:
anti-ganglioside antibody
B-cell lymphoma
Case Report
Glucose
Hypoglossal nerve
hypoglossal nerve palsy
Immunoglobulin M
Immunoglobulins
Internal medicine
Lymphocytes B
Lymphoma
Magnetic resonance imaging
malignant lymphoma
Neurological disorders
Paralysis
Paraneoplastic syndrome
Peripheral nerves
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Summary:Malignant lymphoma sometimes involves peripheral nerves due to paraneoplastic syndrome associated with anti-ganglioside antibodies. We report a very rare case of malignant lymphoma accompanied by an asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies. Magnetic resonance imaging and 18F-2-deoxy-2-fluoro-D-glucose position emission tomography showed no abnormalities of the hypoglossal nerve nucleus; however, the patient' s serum was positive for anti-sulfated glucuronyl paragloboside IgM antibodies as well as anti-GM1 IgM and anti-GQ1b IgM antibodies. The present case might suggest a paraneoplastic asymmetrical and isolated hypoglossal nerve palsy associated with a new subset of anti-ganglioside antibodies.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.1269-18