A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

Per- and polyfluoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. A few PFASs have comparatively extensive amounts of human epidemiological, exposure, and experimental animal t...

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Bibliographic Details
Published in:Environmental health perspectives 2019-01, Vol.127 (1), p.14501-14501
Main Authors: Patlewicz, Grace, Richard, Ann M, Williams, Antony J, Grulke, Christopher M, Sams, Reeder, Lambert, Jason, Noyes, Pamela D, DeVito, Michael J, Hines, Ronald N, Strynar, Mark, Guiseppi-Elie, Annette, Thomas, Russell S
Format: Article
Language:English
Subjects:
Alcohol
Ammonium perfluorooctanoate
Analysis
Biocompatibility
Brief Communication
Chemicals
Environmental aspects
Environmental health
Environmental protection
Epidemiology
Explosives
Exposure
Fluorination
Health aspects
Health hazards
Health risk assessment
Health risks
In vitro methods and tests
In vivo methods and tests
Libraries
Organic chemistry
Perfluoroalkyl & polyfluoroalkyl substances
Perfluorooctanoic acid
R&D
Regulators
Research & development
Risk assessment
Testability
Toxicity
Toxicity testing
Toxicology
Workplace diversity
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Summary:Per- and polyfluoroalkyl substances (PFASs) are a group of fluorinated substances of interest to researchers, regulators, and the public due to their widespread presence in the environment. A few PFASs have comparatively extensive amounts of human epidemiological, exposure, and experimental animal toxicity data (e.g., perfluorooctanoic acid), whereas little toxicity and exposure information exists for much of the broader set of PFASs. Given that traditional approaches to generate toxicity information are resource intensive, new approach methods, including high-throughput toxicity (HTT) testing, are being employed to inform PFAS hazard characterization and further ( ) testing. The U.S. Environmental Protection Agency (EPA) and the National Toxicology Program (NTP) are collaborating to develop a risk-based approach for conducting PFAS toxicity testing to facilitate PFAS human health assessments. This article describes the construction of a PFAS screening library and the process by which a targeted subset of 75 PFASs were selected. Multiple factors were considered, including interest to the U.S. EPA, compounds within targeted categories, structural diversity, exposure considerations, procurability and testability, and availability of existing toxicity data. Generating targeted HTT data for PFASs represents a new frontier for informing priority setting. https://doi.org/10.1289/EHP4555.
ISSN:0091-6765
1552-9924
DOI:10.1289/EHP4555