Neutropenia in the age of genetic testing: Advances and challenges

Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complication...

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Bibliographic Details
Published in:American journal of hematology 2019-03, Vol.94 (3), p.384-393
Main Authors: Furutani, Elissa, Newburger, Peter E., Shimamura, Akiko
Format: Article
Language:English
Subjects:
Cancer
Disease Management
Gene Expression
Genetic Predisposition to Disease
Genetic screening
Genetic testing
Genetic Testing - statistics & numerical data
Germ-Line Mutation
Hematology
Humans
Leukemia - complications
Leukemia - diagnosis
Leukemia - genetics
Leukemia - therapy
Lymphoma - complications
Lymphoma - diagnosis
Lymphoma - genetics
Lymphoma - therapy
Mass Screening - methods
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - diagnosis
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - therapy
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Neutropenia
Neutropenia - complications
Neutropenia - diagnosis
Neutropenia - genetics
Neutropenia - therapy
Practice Guidelines as Topic
Precision medicine
Precision Medicine - methods
Risk Assessment
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Description
Summary:Identification of genetic causes of neutropenia informs precision medicine approaches to medical management and treatment. Accurate diagnosis of genetic neutropenia disorders informs treatment options, enables risk stratification, cancer surveillance, and attention to associated medical complications. The rapidly expanding genetic testing options for the evaluation of neutropenia have led to exciting advances but also new challenges. This review provides a practical guide to germline genetic testing for neutropenia.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.25374