Genomic Features, Comparative Genomics, and Antimicrobial Susceptibility Patterns of Elizabethkingia bruuniana

Elizabethkingia bruuniana is a novel species of the Elizabethkingia genus. There is scant information on this microorganism. Here, we report the whole-genome features and antimicrobial susceptibility patterns of E . bruuniana strain EM798-26. Elizabethkingia strain EM798-26 was initially identified...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.2267-2267, Article 2267
Main Authors: Lin, Jiun-Nong, Lai, Chung-Hsu, Yang, Chih-Hui, Huang, Yi-Han, Lin, Hsi-Hsun
Format: Article
Language:English
Subjects:
45
631/326/1320
631/326/325/1506
Antibiotic resistance
Antibiotics
Antimicrobial agents
Deoxyribonucleic acid
DNA
Gene families
Genes
Genomes
Genomics
Humanities and Social Sciences
Hybridization
Levofloxacin
Minocycline
multidisciplinary
Nucleotide sequence
Phylogeny
Science
Science (multidisciplinary)
Species
Virulence factors
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Summary:Elizabethkingia bruuniana is a novel species of the Elizabethkingia genus. There is scant information on this microorganism. Here, we report the whole-genome features and antimicrobial susceptibility patterns of E . bruuniana strain EM798-26. Elizabethkingia strain EM798-26 was initially identified as E . miricola . This isolate contained a circular genome of 4,393,011 bp. The whole-genome sequence-based phylogeny revealed that Elizabethkingia strain EM798-26 was in the same group of the type strain E . bruuniana G0146 T . Both in silico DNA-DNA hybridization and average nucleotide identity analysis clearly demonstrated that Elizabethkingia strain EM798-26 was a species of E . bruuniana . The pan-genome analysis identified 2,875 gene families in the core genome and 5,199 gene families in the pan genome of eight publicly available E . bruuniana genome sequences. The unique genes accounted for 0.2–12.1% of the pan genome in each E . bruuniana . A total of 59 potential virulence factor homologs were predicted in the whole-genome of E . bruuniana strain EM798–26. This isolate was nonsusceptible to multiple antibiotics, but susceptible to aminoglycosides, minocycline, and levofloxacin. The whole-genome sequence analysis of E . bruuniana EM798-26 revealed 29 homologs of antibiotic resistance-related genes. This study presents the genomic features of E . bruuniana . Knowledge of the genomic characteristics provides valuable insights into a novel species.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-38998-6