Scaling of Motor Output, From Mouse to Humans

Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scalin...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2019-01, Vol.34 (1), p.5-13
Main Authors: Manuel, Marin, Chardon, Matthieu, Tysseling, Vicki, Heckman, C J
Format: Article
Language:English
Subjects:
Animals
Cognitive science
Humans
Mice
Motor Neurons - physiology
Movement - physiology
Muscle, Skeletal - metabolism
Neuroscience
Review
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Summary:Appropriate scaling of motor output from mouse to humans is essential. The motoneurons that generate all motor output are, however, very different in rodents compared with humans, being smaller and much more excitable. In contrast, feline motoneurons are more similar to those in humans. These scaling differences need to be taken into account for the use of rodents for translational studies of motor output.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00021.2018