The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases

Long non-coding RNAs (lncRNAs) are involved in a variety of biological and cellular processes as well as in physiologic and pathophysiologic events. This review summarizes recent literature about the role of the lncRNA nuclear enriched abundant transcript 1 ( ) in non-cancerous diseases with a speci...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-02, Vol.20 (3), p.627
Main Authors: Prinz, Felix, Kapeller, Anita, Pichler, Martin, Klec, Christiane
Format: Article
Language:English
Subjects:
Adenosine
Breast cancer
Cancer
Carcinogenesis
Carcinogens
Cytoplasm
Editing
Gene expression
Hepatocellular carcinoma
Immune response
Interleukin 8
Liver cancer
Lung cancer
MicroRNAs
Neurodegeneration
Non-coding RNA
Ovarian cancer
Physiology
Prostate
Prostate cancer
Proteins
Retention
Review
Stem cells
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Summary:Long non-coding RNAs (lncRNAs) are involved in a variety of biological and cellular processes as well as in physiologic and pathophysiologic events. This review summarizes recent literature about the role of the lncRNA nuclear enriched abundant transcript 1 ( ) in non-cancerous diseases with a special focus on viral infections and neurodegenerative diseases. In contrast to its role as competing endogenous RNA (ceRNA) in carcinogenesis, 's function in non-cancerous diseases predominantly focuses on paraspeckle-mediated effects on gene expression. This involves processes such as nuclear retention of mRNAs or sequestration of paraspeckle proteins from specific promoters, resulting in transcriptional induction or repression of genes involved in regulating the immune system or neurodegenerative processes. expression is aberrantly-mostly upregulated-in non-cancerous pathological conditions, indicating that it could serve as potential prognostic biomarker. Additional studies are needed to elucidate 's capability to be a therapeutic target for non-cancerous diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20030627