Probing the happy place

A variety of neurological procedures, including deep brain stimulation and craniotomies that require tissue removal near elegant cortices, require patients to remain awake and responsive in order to monitor function. Such procedures can produce anxiety and are poorly tolerated in some subjects. In t...

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Bibliographic Details
Published in:The Journal of clinical investigation 2019-03, Vol.129 (3), p.952-954
Main Author: Mills, Kelly A
Format: Article
Language:English
Subjects:
Analysis
Anxiety
Behavior
Biomedical research
Brain Neoplasms
Care and treatment
Cingulum
Craniotomy
Deep Brain Stimulation
Drug therapy
Electric stimulation
Electrical stimuli
Epilepsy
Facial Expression
Humans
Medical schools
Neurophysiology
Neurosurgery
Parkinson's disease
Patient outcomes
Patients
Surgery
Systematic review
Tourette syndrome
Treatment outcome
Wakefulness
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Summary:A variety of neurological procedures, including deep brain stimulation and craniotomies that require tissue removal near elegant cortices, require patients to remain awake and responsive in order to monitor function. Such procedures can produce anxiety and are poorly tolerated in some subjects. In this issue of the JCI, Bijanki and colleagues demonstrate that electrical stimulation of the left dorsal anterior cingulum bundle promoted a positive (mirthful) effect and reduced anxiety, without sedation, in three patients with epilepsy undergoing intracranial electrode monitoring. The results of this study highlight the need for further evaluation of anterior cingulum stimulation to reduce anxiety during awake surgery and as a possible approach for treating anxiety disorders.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI126683