Loading…
Self‐Orienting Hydrogel Micro‐Buckets as Novel Cell Carriers
Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self‐orientation of crescent‐shaped hydrogel microparticles and elucidate its mechanism. Additionally, the micropa...
Saved in:
Published in: | Angewandte Chemie International Edition 2019-01, Vol.58 (2), p.547-551 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3 |
---|---|
cites | cdi_FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3 |
container_end_page | 551 |
container_issue | 2 |
container_start_page | 547 |
container_title | Angewandte Chemie International Edition |
container_volume | 58 |
creator | Liu, Qian Zhao, Meng Mytnyk, Serhii Klemm, Benjamin Zhang, Kai Wang, Yiming Yan, Dadong Mendes, Eduardo van Esch, Jan H. |
description | Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self‐orientation of crescent‐shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as micro‐buckets to carry living cells. In aqueous solution, the microparticles spontaneously rotated to a preferred orientation with the cavity facing up. We developed a geometric model that explains the self‐orienting behavior of crescent‐shaped particles by minimizing the potential energy of this specific morphology. Finally, we selectively modified the particles’ cavities with RGD peptide and exploited their preferred orientation to load them with living cells. Cells could adhere, proliferate, and be transported and released in vitro. These micro‐buckets hold a great potential for applications in smart materials, cell therapy, and biological engineering.
There’s a cell in my bucket: The self‐orientation of crescent‐shaped hydrogel microparticles was reported and its mechanism elucidated. These microparticles were used as cell carriers for cell loading, transport, proliferation, and release after functionalization with cell‐adhesive peptides. This provides a new strategy for manipulation of microparticles with potential applications in biomaterials, tissue architecture, and cell delivery. |
doi_str_mv | 10.1002/anie.201811374 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391985</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2163190132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3</originalsourceid><addsrcrecordid>eNqFkTtPwzAUhS0E4r0yokosLCm-vnFiL4hS8ZJ4DMBsuY5TDGkCdgPqxk_gN_JLcFUoj4XFtnS-e3SPDyFbQLtAKdvTtbNdRkEAYJ4ukFXgDBLMc1yM7xQxyQWHFbIWwn3khaDZMllBipKjyFbJwbWtyvfXtyvvbD129bBzOil8M7RV58IZ30TpsDUPdhw6OnQum-co9G0VD-3jiA8bZKnUVbCbn_c6uT0-uumfJudXJ2f93nliOOVpYqQ2ojADhjkdlFgIlKwQUtIcUKJJtbZloWlWslKbQUqZoZkEXhhujYVc4zrZn_k-toORLUzc1utKPXo30n6iGu3Ub6V2d2rYPKsMJUjBo8Hup4FvnlobxmrkgolRdG2bNigGSCnPQLCI7vxB75vW1zFepDIESQGnVHdGxW8KwdtyvgxQNS1HTctR83LiwPbPCHP8q40IyBnw4io7-cdO9S7Pjr7NPwC7ZZ2x</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2163190132</pqid></control><display><type>article</type><title>Self‐Orienting Hydrogel Micro‐Buckets as Novel Cell Carriers</title><source>Wiley</source><creator>Liu, Qian ; Zhao, Meng ; Mytnyk, Serhii ; Klemm, Benjamin ; Zhang, Kai ; Wang, Yiming ; Yan, Dadong ; Mendes, Eduardo ; van Esch, Jan H.</creator><creatorcontrib>Liu, Qian ; Zhao, Meng ; Mytnyk, Serhii ; Klemm, Benjamin ; Zhang, Kai ; Wang, Yiming ; Yan, Dadong ; Mendes, Eduardo ; van Esch, Jan H.</creatorcontrib><description>Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self‐orientation of crescent‐shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as micro‐buckets to carry living cells. In aqueous solution, the microparticles spontaneously rotated to a preferred orientation with the cavity facing up. We developed a geometric model that explains the self‐orienting behavior of crescent‐shaped particles by minimizing the potential energy of this specific morphology. Finally, we selectively modified the particles’ cavities with RGD peptide and exploited their preferred orientation to load them with living cells. Cells could adhere, proliferate, and be transported and released in vitro. These micro‐buckets hold a great potential for applications in smart materials, cell therapy, and biological engineering.
There’s a cell in my bucket: The self‐orientation of crescent‐shaped hydrogel microparticles was reported and its mechanism elucidated. These microparticles were used as cell carriers for cell loading, transport, proliferation, and release after functionalization with cell‐adhesive peptides. This provides a new strategy for manipulation of microparticles with potential applications in biomaterials, tissue architecture, and cell delivery.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201811374</identifier><identifier>PMID: 30395386</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Aqueous solutions ; Bioengineering ; Buckets ; cell carriers ; Cells (biology) ; Cells - metabolism ; Communication ; Communications ; Holes ; Humans ; Hydrogels ; Hydrogels - metabolism ; Materials engineering ; Mathematical morphology ; microfluidics ; Microfluidics - methods ; Microparticles ; Orientation behavior ; Potential energy ; Preferred orientation ; self-orientation ; Smart materials ; soft matter</subject><ispartof>Angewandte Chemie International Edition, 2019-01, Vol.58 (2), p.547-551</ispartof><rights>2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.</rights><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3</citedby><cites>FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3</cites><orcidid>0000-0002-0110-9433 ; 0000-0001-6116-4808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30395386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Zhao, Meng</creatorcontrib><creatorcontrib>Mytnyk, Serhii</creatorcontrib><creatorcontrib>Klemm, Benjamin</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Wang, Yiming</creatorcontrib><creatorcontrib>Yan, Dadong</creatorcontrib><creatorcontrib>Mendes, Eduardo</creatorcontrib><creatorcontrib>van Esch, Jan H.</creatorcontrib><title>Self‐Orienting Hydrogel Micro‐Buckets as Novel Cell Carriers</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self‐orientation of crescent‐shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as micro‐buckets to carry living cells. In aqueous solution, the microparticles spontaneously rotated to a preferred orientation with the cavity facing up. We developed a geometric model that explains the self‐orienting behavior of crescent‐shaped particles by minimizing the potential energy of this specific morphology. Finally, we selectively modified the particles’ cavities with RGD peptide and exploited their preferred orientation to load them with living cells. Cells could adhere, proliferate, and be transported and released in vitro. These micro‐buckets hold a great potential for applications in smart materials, cell therapy, and biological engineering.
There’s a cell in my bucket: The self‐orientation of crescent‐shaped hydrogel microparticles was reported and its mechanism elucidated. These microparticles were used as cell carriers for cell loading, transport, proliferation, and release after functionalization with cell‐adhesive peptides. This provides a new strategy for manipulation of microparticles with potential applications in biomaterials, tissue architecture, and cell delivery.</description><subject>Aqueous solutions</subject><subject>Bioengineering</subject><subject>Buckets</subject><subject>cell carriers</subject><subject>Cells (biology)</subject><subject>Cells - metabolism</subject><subject>Communication</subject><subject>Communications</subject><subject>Holes</subject><subject>Humans</subject><subject>Hydrogels</subject><subject>Hydrogels - metabolism</subject><subject>Materials engineering</subject><subject>Mathematical morphology</subject><subject>microfluidics</subject><subject>Microfluidics - methods</subject><subject>Microparticles</subject><subject>Orientation behavior</subject><subject>Potential energy</subject><subject>Preferred orientation</subject><subject>self-orientation</subject><subject>Smart materials</subject><subject>soft matter</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkTtPwzAUhS0E4r0yokosLCm-vnFiL4hS8ZJ4DMBsuY5TDGkCdgPqxk_gN_JLcFUoj4XFtnS-e3SPDyFbQLtAKdvTtbNdRkEAYJ4ukFXgDBLMc1yM7xQxyQWHFbIWwn3khaDZMllBipKjyFbJwbWtyvfXtyvvbD129bBzOil8M7RV58IZ30TpsDUPdhw6OnQum-co9G0VD-3jiA8bZKnUVbCbn_c6uT0-uumfJudXJ2f93nliOOVpYqQ2ojADhjkdlFgIlKwQUtIcUKJJtbZloWlWslKbQUqZoZkEXhhujYVc4zrZn_k-toORLUzc1utKPXo30n6iGu3Ub6V2d2rYPKsMJUjBo8Hup4FvnlobxmrkgolRdG2bNigGSCnPQLCI7vxB75vW1zFepDIESQGnVHdGxW8KwdtyvgxQNS1HTctR83LiwPbPCHP8q40IyBnw4io7-cdO9S7Pjr7NPwC7ZZ2x</recordid><startdate>20190108</startdate><enddate>20190108</enddate><creator>Liu, Qian</creator><creator>Zhao, Meng</creator><creator>Mytnyk, Serhii</creator><creator>Klemm, Benjamin</creator><creator>Zhang, Kai</creator><creator>Wang, Yiming</creator><creator>Yan, Dadong</creator><creator>Mendes, Eduardo</creator><creator>van Esch, Jan H.</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0110-9433</orcidid><orcidid>https://orcid.org/0000-0001-6116-4808</orcidid></search><sort><creationdate>20190108</creationdate><title>Self‐Orienting Hydrogel Micro‐Buckets as Novel Cell Carriers</title><author>Liu, Qian ; Zhao, Meng ; Mytnyk, Serhii ; Klemm, Benjamin ; Zhang, Kai ; Wang, Yiming ; Yan, Dadong ; Mendes, Eduardo ; van Esch, Jan H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aqueous solutions</topic><topic>Bioengineering</topic><topic>Buckets</topic><topic>cell carriers</topic><topic>Cells (biology)</topic><topic>Cells - metabolism</topic><topic>Communication</topic><topic>Communications</topic><topic>Holes</topic><topic>Humans</topic><topic>Hydrogels</topic><topic>Hydrogels - metabolism</topic><topic>Materials engineering</topic><topic>Mathematical morphology</topic><topic>microfluidics</topic><topic>Microfluidics - methods</topic><topic>Microparticles</topic><topic>Orientation behavior</topic><topic>Potential energy</topic><topic>Preferred orientation</topic><topic>self-orientation</topic><topic>Smart materials</topic><topic>soft matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Zhao, Meng</creatorcontrib><creatorcontrib>Mytnyk, Serhii</creatorcontrib><creatorcontrib>Klemm, Benjamin</creatorcontrib><creatorcontrib>Zhang, Kai</creatorcontrib><creatorcontrib>Wang, Yiming</creatorcontrib><creatorcontrib>Yan, Dadong</creatorcontrib><creatorcontrib>Mendes, Eduardo</creatorcontrib><creatorcontrib>van Esch, Jan H.</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Online Library website</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Qian</au><au>Zhao, Meng</au><au>Mytnyk, Serhii</au><au>Klemm, Benjamin</au><au>Zhang, Kai</au><au>Wang, Yiming</au><au>Yan, Dadong</au><au>Mendes, Eduardo</au><au>van Esch, Jan H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self‐Orienting Hydrogel Micro‐Buckets as Novel Cell Carriers</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2019-01-08</date><risdate>2019</risdate><volume>58</volume><issue>2</issue><spage>547</spage><epage>551</epage><pages>547-551</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Hydrogel microparticles are important in materials engineering, but their applications remain limited owing to the difficulties associated with their manipulation. Herein, we report the self‐orientation of crescent‐shaped hydrogel microparticles and elucidate its mechanism. Additionally, the microparticles were used, for the first time, as micro‐buckets to carry living cells. In aqueous solution, the microparticles spontaneously rotated to a preferred orientation with the cavity facing up. We developed a geometric model that explains the self‐orienting behavior of crescent‐shaped particles by minimizing the potential energy of this specific morphology. Finally, we selectively modified the particles’ cavities with RGD peptide and exploited their preferred orientation to load them with living cells. Cells could adhere, proliferate, and be transported and released in vitro. These micro‐buckets hold a great potential for applications in smart materials, cell therapy, and biological engineering.
There’s a cell in my bucket: The self‐orientation of crescent‐shaped hydrogel microparticles was reported and its mechanism elucidated. These microparticles were used as cell carriers for cell loading, transport, proliferation, and release after functionalization with cell‐adhesive peptides. This provides a new strategy for manipulation of microparticles with potential applications in biomaterials, tissue architecture, and cell delivery.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30395386</pmid><doi>10.1002/anie.201811374</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0002-0110-9433</orcidid><orcidid>https://orcid.org/0000-0001-6116-4808</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1433-7851 |
ispartof | Angewandte Chemie International Edition, 2019-01, Vol.58 (2), p.547-551 |
issn | 1433-7851 1521-3773 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6391985 |
source | Wiley |
subjects | Aqueous solutions Bioengineering Buckets cell carriers Cells (biology) Cells - metabolism Communication Communications Holes Humans Hydrogels Hydrogels - metabolism Materials engineering Mathematical morphology microfluidics Microfluidics - methods Microparticles Orientation behavior Potential energy Preferred orientation self-orientation Smart materials soft matter |
title | Self‐Orienting Hydrogel Micro‐Buckets as Novel Cell Carriers |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A24%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Self%E2%80%90Orienting%20Hydrogel%20Micro%E2%80%90Buckets%20as%20Novel%20Cell%20Carriers&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.au=Liu,%20Qian&rft.date=2019-01-08&rft.volume=58&rft.issue=2&rft.spage=547&rft.epage=551&rft.pages=547-551&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.201811374&rft_dat=%3Cproquest_pubme%3E2163190132%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5054-c9ac8dcb2370bf3d8392d899071393c4aaefda06f2facb402c06915dc5ece17a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2163190132&rft_id=info:pmid/30395386&rfr_iscdi=true |