Effects of gender and age on prevalence of cholelithiasis in patients with chronic HCV infection: A community-based cross-sectional study in an HCV-hyperendemic area

This study investigated the effects of age and gender on the prevalence of cholelithiasis in patients with chronic HCV infection.Demographic and clinical data of 8489 subjects (3671 males, 4818 females; mean age 47.5 years) receiving township-wide health examinations between September 2012 and Augus...

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Published in:Medicine (Baltimore) 2018-06, Vol.97 (22), p.e10846-e10846
Main Authors: Hu, Jing-Hong, Chen, Mei-Yen, Yeh, Chau-Ting, Chiu, Wen-Nan, Chiang, Ming-shih, Chang, Ming-Ling
Format: Article
Language:English
Subjects:
Age Factors
Cholelithiasis - epidemiology
Cholelithiasis - virology
Cross-Sectional Studies
Female
Hepatitis C, Chronic - complications
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Observational Study
Prevalence
Risk Factors
Sex Factors
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container_title Medicine (Baltimore)
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creator Hu, Jing-Hong
Chen, Mei-Yen
Yeh, Chau-Ting
Chiu, Wen-Nan
Chiang, Ming-shih
Chang, Ming-Ling
description This study investigated the effects of age and gender on the prevalence of cholelithiasis in patients with chronic HCV infection.Demographic and clinical data of 8489 subjects (3671 males, 4818 females; mean age 47.5 years) receiving township-wide health examinations between September 2012 and August 2013 were analyzed. The main endpoint was prevalence of cholelithiasis. Risk factors (age, gender, body mass index, concomitant diseases, lifestyle, laboratory parameters, and HCV status) were evaluated. Univariate and multivariate logistic regression analyses were performed to identify associations between cholelithiasis and variables.Cholelithiasis was more prevalent among HCV subjects than non-HCV subjects (females: 8.1% vs 4.2%; males: 9.1% vs 3.9%; both P 55 vs
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The main endpoint was prevalence of cholelithiasis. Risk factors (age, gender, body mass index, concomitant diseases, lifestyle, laboratory parameters, and HCV status) were evaluated. Univariate and multivariate logistic regression analyses were performed to identify associations between cholelithiasis and variables.Cholelithiasis was more prevalent among HCV subjects than non-HCV subjects (females: 8.1% vs 4.2%; males: 9.1% vs 3.9%; both P &lt; .001); rates ranged from 5.6% to 8.3% in females and 4.7% to 10.6% in males. HCV status and age were associated with cholelithiasis occurrence (OR = 2.17 for HCV vs non-HCV; OR = 2.44, 3.54 for age 45-55, and &gt;55 vs &lt;45 years; all P &lt; .05). Multivariate analysis showed a significant association between cholelithiasis and age/sex interaction terms (OR = 0.517 for age &gt;55 vs &lt;45 for sex; P = .011). Cholelithiasis prevalence was significantly associated between age and sex interaction terms but not anymore if considering positive HCV status. All noninvasive tests for liver fibrosis were associated with cholelithiasis but only fibrosis-4 index was significantly associated (OR = 1.28, P = .019).Age, gender, and HCV infection are associated with increased risk and prevalence of cholelithiasis. After age of 55 years, cholelithiasis is more prevalent among HCV-positive males than females. Females of age 55 and more may be protected against cholelithiasis as sex hormones decrease.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000010846</identifier><identifier>PMID: 29851796</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Age Factors ; Cholelithiasis - epidemiology ; Cholelithiasis - virology ; Cross-Sectional Studies ; Female ; Hepatitis C, Chronic - complications ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Observational Study ; Prevalence ; Risk Factors ; Sex Factors</subject><ispartof>Medicine (Baltimore), 2018-06, Vol.97 (22), p.e10846-e10846</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2854-c33110adc8e86c64f298936e40a797ee1e2314c6ad495447c7cc68946d9fa1e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392741/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392741/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29851796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Jing-Hong</creatorcontrib><creatorcontrib>Chen, Mei-Yen</creatorcontrib><creatorcontrib>Yeh, Chau-Ting</creatorcontrib><creatorcontrib>Chiu, Wen-Nan</creatorcontrib><creatorcontrib>Chiang, Ming-shih</creatorcontrib><creatorcontrib>Chang, Ming-Ling</creatorcontrib><title>Effects of gender and age on prevalence of cholelithiasis in patients with chronic HCV infection: A community-based cross-sectional study in an HCV-hyperendemic area</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>This study investigated the effects of age and gender on the prevalence of cholelithiasis in patients with chronic HCV infection.Demographic and clinical data of 8489 subjects (3671 males, 4818 females; mean age 47.5 years) receiving township-wide health examinations between September 2012 and August 2013 were analyzed. The main endpoint was prevalence of cholelithiasis. Risk factors (age, gender, body mass index, concomitant diseases, lifestyle, laboratory parameters, and HCV status) were evaluated. Univariate and multivariate logistic regression analyses were performed to identify associations between cholelithiasis and variables.Cholelithiasis was more prevalent among HCV subjects than non-HCV subjects (females: 8.1% vs 4.2%; males: 9.1% vs 3.9%; both P &lt; .001); rates ranged from 5.6% to 8.3% in females and 4.7% to 10.6% in males. HCV status and age were associated with cholelithiasis occurrence (OR = 2.17 for HCV vs non-HCV; OR = 2.44, 3.54 for age 45-55, and &gt;55 vs &lt;45 years; all P &lt; .05). Multivariate analysis showed a significant association between cholelithiasis and age/sex interaction terms (OR = 0.517 for age &gt;55 vs &lt;45 for sex; P = .011). Cholelithiasis prevalence was significantly associated between age and sex interaction terms but not anymore if considering positive HCV status. All noninvasive tests for liver fibrosis were associated with cholelithiasis but only fibrosis-4 index was significantly associated (OR = 1.28, P = .019).Age, gender, and HCV infection are associated with increased risk and prevalence of cholelithiasis. After age of 55 years, cholelithiasis is more prevalent among HCV-positive males than females. Females of age 55 and more may be protected against cholelithiasis as sex hormones decrease.</description><subject>Age Factors</subject><subject>Cholelithiasis - epidemiology</subject><subject>Cholelithiasis - virology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Observational Study</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkctu1DAUhi0EokPhCZCQl2zS-hYnZoFUTUuL1IoNsLVc52RicOzBTjqaB-I9cTqlXLyxdP7_fOeG0GtKTihRzenN-Qn58yhphXyCVrTmsqqVFE_RihBWV41qxBF6kfO3YuINE8_REVNtTRslV-jnRd-DnTKOPd5A6CBhEzpsNoBjwNsEd8ZDsLDodogevJsGZ7LL2BXdTA5Cyd6VaNFTDM7iq_XXIi5YF8M7fIZtHMc5uGlf3ZoMHbYp5lzlg8F4nKe52y88E5bkathvIS3NjIVmEpiX6FlvfIZXD_8x-vLh4vP6qrr-dPlxfXZdWdbWorKcU0pMZ1topZWiL3MqLkEQU7YAQIFxKqw0nVC1EI1trJWtErJTvaHA-TF6f-Bu59sROltmS8brbXKjSXsdjdP_KsENehPvtOSKNYIWwNsHQIo_ZsiTHl224L0JEOesGSmVa8poW6z8YL3fRoL-sQwlejmwvjnX_x-4ZL35u8PHnN8XLQZxMOyinyDl737eQdIDGD8N97y6UaxihLZEFmhVIkzwX-sos68</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Hu, Jing-Hong</creator><creator>Chen, Mei-Yen</creator><creator>Yeh, Chau-Ting</creator><creator>Chiu, Wen-Nan</creator><creator>Chiang, Ming-shih</creator><creator>Chang, Ming-Ling</creator><general>The Authors. 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The main endpoint was prevalence of cholelithiasis. Risk factors (age, gender, body mass index, concomitant diseases, lifestyle, laboratory parameters, and HCV status) were evaluated. Univariate and multivariate logistic regression analyses were performed to identify associations between cholelithiasis and variables.Cholelithiasis was more prevalent among HCV subjects than non-HCV subjects (females: 8.1% vs 4.2%; males: 9.1% vs 3.9%; both P &lt; .001); rates ranged from 5.6% to 8.3% in females and 4.7% to 10.6% in males. HCV status and age were associated with cholelithiasis occurrence (OR = 2.17 for HCV vs non-HCV; OR = 2.44, 3.54 for age 45-55, and &gt;55 vs &lt;45 years; all P &lt; .05). Multivariate analysis showed a significant association between cholelithiasis and age/sex interaction terms (OR = 0.517 for age &gt;55 vs &lt;45 for sex; P = .011). Cholelithiasis prevalence was significantly associated between age and sex interaction terms but not anymore if considering positive HCV status. All noninvasive tests for liver fibrosis were associated with cholelithiasis but only fibrosis-4 index was significantly associated (OR = 1.28, P = .019).Age, gender, and HCV infection are associated with increased risk and prevalence of cholelithiasis. After age of 55 years, cholelithiasis is more prevalent among HCV-positive males than females. Females of age 55 and more may be protected against cholelithiasis as sex hormones decrease.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>29851796</pmid><doi>10.1097/MD.0000000000010846</doi><oa>free_for_read</oa></addata></record>
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subjects Age Factors
Cholelithiasis - epidemiology
Cholelithiasis - virology
Cross-Sectional Studies
Female
Hepatitis C, Chronic - complications
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Observational Study
Prevalence
Risk Factors
Sex Factors
title Effects of gender and age on prevalence of cholelithiasis in patients with chronic HCV infection: A community-based cross-sectional study in an HCV-hyperendemic area
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