The side effects and complications of percutaneous iodine-125 seeds implantation under CT-guide for patients with advanced pancreatic cancer

The present study investigates the side effects and complications of computed tomography (CT)-guided percutaneous iodine-125 (I-125) seeds implantation for advanced pancreatic cancer. The clinical data were retrospectively analyzed for patients treated with implantation of I-125 seeds under CT-guide...

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Bibliographic Details
Published in:Medicine (Baltimore) 2017-12, Vol.96 (52), p.e9535-e9535
Main Authors: Lv, Wei-Fu, Lu, Dong, Xiao, Jing-Kun, Mukhiya, Gauri, Tan, Zhong-Xiao, Cheng, De-Lei, Zhou, Chun-Ze, Zhang, Xing-Min, Zhang, Zheng-Feng, Hou, Chang-Long
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brachytherapy - adverse effects
Brachytherapy - methods
Female
Humans
Iodine Radioisotopes - therapeutic use
Male
Middle Aged
Observational Study
Pancreatic Neoplasms - radiotherapy
Radiography, Interventional
Retrospective Studies
Tomography, X-Ray Computed
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Summary:The present study investigates the side effects and complications of computed tomography (CT)-guided percutaneous iodine-125 (I-125) seeds implantation for advanced pancreatic cancer. The clinical data were retrospectively analyzed for patients treated with implantation of I-125 seeds under CT-guide in our hospital from May 2010 to April 2015. The side effects and complications were collected and their possible reasons were analyzed. A total of 78 patients were enrolled. The side effects were categorized as fever in 29 cases (37.18%), abdominal pain in 26 cases (33.33%), nausea and vomiting in 9 cases (11.54%), diarrhea in 5 cases (6.41%), and constipation in 4 cases (5.13%). Complications were composed of pancreatitis in 9 cases (11.54%), infection in 5 cases (6.41%), seed migration in 2 cases (2.56%), intestinal perforation in 1 case (1.28%), and intestinal obstruction in 1 case. The incidence of complication was 23.08% (18/78). The difference in incidence of complication was statistically significant between patients implanted with ≤27 seeds and those with >27 seeds (P = .032). The side effects and complications frequently occur in implantation of I-125 seeds for patients with advanced pancreatic cancer. More concern should be given to the patients treated by this technique.
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000009535