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Exercise intensity and middle cerebral artery dynamics in humans
•Stimulus-response profiles during exercise are important for understanding control processes.•Middle cerebral artery blood flow velocity increased systematically with work rate.•Amplitude response associated with age and estimated fitness.•Maintaining fitness may benefit cerebrovascular response ac...
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| Published in: | Respiratory physiology & neurobiology 2019-04, Vol.262, p.32-39 |
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| Main Authors: | , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c455t-483cb7e2ed40a306d1330e9594d71f53f22e71cd0e0017873d471b41b8fc2b723 |
| container_end_page | 39 |
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| container_title | Respiratory physiology & neurobiology |
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| creator | Witte, Emily Liu, Yumei Ward, Jaimie L. Kempf, Katie S. Whitaker, Alicen Vidoni, Eric D. Craig, Jesse C. Poole, David C. Billinger, Sandra A. |
| description | •Stimulus-response profiles during exercise are important for understanding control processes.•Middle cerebral artery blood flow velocity increased systematically with work rate.•Amplitude response associated with age and estimated fitness.•Maintaining fitness may benefit cerebrovascular response across aging.
Despite its necessity for understanding healthy brain aging, the influence of exercise intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized middle cerebral artery blood flow velocity (MCAv) kinetics associated with two exercise intensities: low and moderate. We hypothesized that increasing exercise intensity would increase the MCAv amplitude response (Amp) and that age and estimated fitness (V̇O2max) would be related to Amp. Baseline (BL) values were collected for 90-seconds followed by a 6-minute exercise bout. Heart rate, end-tidal CO2, mean arterial pressure and MCAv were recorded throughout. MCAv kinetics were described by Amp, time delay (TD) and time constant (τ). Sixty-four adults completed the study. Amp was greater during moderate compared to low exercise intensity (p |
| doi_str_mv | 10.1016/j.resp.2019.01.013 |
| format | article |
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Despite its necessity for understanding healthy brain aging, the influence of exercise intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized middle cerebral artery blood flow velocity (MCAv) kinetics associated with two exercise intensities: low and moderate. We hypothesized that increasing exercise intensity would increase the MCAv amplitude response (Amp) and that age and estimated fitness (V̇O2max) would be related to Amp. Baseline (BL) values were collected for 90-seconds followed by a 6-minute exercise bout. Heart rate, end-tidal CO2, mean arterial pressure and MCAv were recorded throughout. MCAv kinetics were described by Amp, time delay (TD) and time constant (τ). Sixty-four adults completed the study. Amp was greater during moderate compared to low exercise intensity (p < 0.001) while no difference was observed in either TD (p = 0.65) or τ (p = 0.47). Amp was negatively associated with age (p < 0.01) and positively correlated with estimated V̇O2max (p < 0.01). Although Amp declines with age, maintaining higher V̇O2max may benefit the cerebrovascular response to exercise.</description><identifier>ISSN: 1569-9048</identifier><identifier>ISSN: 1878-1519</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2019.01.013</identifier><identifier>PMID: 30710650</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acute exercise ; Adult ; Aerobic fitness ; Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Blood Flow Velocity ; Blood pressure ; Blood Pressure - physiology ; Cardiorespiratory Fitness - physiology ; Cerebral blood flow velocity ; Exercise - physiology ; Female ; Heart Rate - physiology ; Humans ; Male ; Middle Aged ; Middle cerebral artery ; Middle Cerebral Artery - diagnostic imaging ; Middle Cerebral Artery - physiology ; Ultrasonography, Doppler, Transcranial ; Young Adult</subject><ispartof>Respiratory physiology & neurobiology, 2019-04, Vol.262, p.32-39</ispartof><rights>2019 Elsevier B.V.</rights><rights>Copyright © 2019 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-483cb7e2ed40a306d1330e9594d71f53f22e71cd0e0017873d471b41b8fc2b723</citedby><cites>FETCH-LOGICAL-c455t-483cb7e2ed40a306d1330e9594d71f53f22e71cd0e0017873d471b41b8fc2b723</cites><orcidid>0000-0002-1618-7207 ; 0000-0001-5181-7131</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30710650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Witte, Emily</creatorcontrib><creatorcontrib>Liu, Yumei</creatorcontrib><creatorcontrib>Ward, Jaimie L.</creatorcontrib><creatorcontrib>Kempf, Katie S.</creatorcontrib><creatorcontrib>Whitaker, Alicen</creatorcontrib><creatorcontrib>Vidoni, Eric D.</creatorcontrib><creatorcontrib>Craig, Jesse C.</creatorcontrib><creatorcontrib>Poole, David C.</creatorcontrib><creatorcontrib>Billinger, Sandra A.</creatorcontrib><title>Exercise intensity and middle cerebral artery dynamics in humans</title><title>Respiratory physiology & neurobiology</title><addtitle>Respir Physiol Neurobiol</addtitle><description>•Stimulus-response profiles during exercise are important for understanding control processes.•Middle cerebral artery blood flow velocity increased systematically with work rate.•Amplitude response associated with age and estimated fitness.•Maintaining fitness may benefit cerebrovascular response across aging.
Despite its necessity for understanding healthy brain aging, the influence of exercise intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized middle cerebral artery blood flow velocity (MCAv) kinetics associated with two exercise intensities: low and moderate. We hypothesized that increasing exercise intensity would increase the MCAv amplitude response (Amp) and that age and estimated fitness (V̇O2max) would be related to Amp. Baseline (BL) values were collected for 90-seconds followed by a 6-minute exercise bout. Heart rate, end-tidal CO2, mean arterial pressure and MCAv were recorded throughout. MCAv kinetics were described by Amp, time delay (TD) and time constant (τ). Sixty-four adults completed the study. Amp was greater during moderate compared to low exercise intensity (p < 0.001) while no difference was observed in either TD (p = 0.65) or τ (p = 0.47). Amp was negatively associated with age (p < 0.01) and positively correlated with estimated V̇O2max (p < 0.01). Although Amp declines with age, maintaining higher V̇O2max may benefit the cerebrovascular response to exercise.</description><subject>Acute exercise</subject><subject>Adult</subject><subject>Aerobic fitness</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Blood Flow Velocity</subject><subject>Blood pressure</subject><subject>Blood Pressure - physiology</subject><subject>Cardiorespiratory Fitness - physiology</subject><subject>Cerebral blood flow velocity</subject><subject>Exercise - physiology</subject><subject>Female</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Middle cerebral artery</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Middle Cerebral Artery - physiology</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Young Adult</subject><issn>1569-9048</issn><issn>1878-1519</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMo7vrxBzxIj166Zpq2aUBEkfUDBC96Dmky1SxtuiZdcf-9KbuKXoSBGZh33nl5CDkBOgMK5fli5jEsZxkFMaMQi-2QKVS8SqEAsRvnohSpoHk1IQchLCgFDpztkwmjHGhZ0Cm5mn-i1zZgYt2ALthhnShnks4a02Ki0WPtVZsoP6BfJ2btVGd1iOrkbdUpF47IXqPagMfbfkhebufPN_fp49Pdw831Y6rzohjSvGK65pihyalitDTAGEVRiNxwaArWZBly0IbimLLizOQc6hzqqtFZzTN2SC43vstV3aHR6IaYSy697ZRfy15Z-Xfj7Jt87T9kyQSLiKLB2dbA9-8rDIPsbNDYtsphvwoyAy5yXohq_JVtpNr3IXhsft4AlSN6uZAjejmilxRisXh0-jvgz8k36yi42AgwYvqw6GXQFp1GYz3qQZre_uf_BTaglc4</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Witte, Emily</creator><creator>Liu, Yumei</creator><creator>Ward, Jaimie L.</creator><creator>Kempf, Katie S.</creator><creator>Whitaker, Alicen</creator><creator>Vidoni, Eric D.</creator><creator>Craig, Jesse C.</creator><creator>Poole, David C.</creator><creator>Billinger, Sandra A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1618-7207</orcidid><orcidid>https://orcid.org/0000-0001-5181-7131</orcidid></search><sort><creationdate>20190401</creationdate><title>Exercise intensity and middle cerebral artery dynamics in humans</title><author>Witte, Emily ; Liu, Yumei ; Ward, Jaimie L. ; Kempf, Katie S. ; Whitaker, Alicen ; Vidoni, Eric D. ; Craig, Jesse C. ; Poole, David C. ; Billinger, Sandra A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-483cb7e2ed40a306d1330e9594d71f53f22e71cd0e0017873d471b41b8fc2b723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute exercise</topic><topic>Adult</topic><topic>Aerobic fitness</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Blood Flow Velocity</topic><topic>Blood pressure</topic><topic>Blood Pressure - physiology</topic><topic>Cardiorespiratory Fitness - physiology</topic><topic>Cerebral blood flow velocity</topic><topic>Exercise - physiology</topic><topic>Female</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Middle cerebral artery</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Middle Cerebral Artery - physiology</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Witte, Emily</creatorcontrib><creatorcontrib>Liu, Yumei</creatorcontrib><creatorcontrib>Ward, Jaimie L.</creatorcontrib><creatorcontrib>Kempf, Katie S.</creatorcontrib><creatorcontrib>Whitaker, Alicen</creatorcontrib><creatorcontrib>Vidoni, Eric D.</creatorcontrib><creatorcontrib>Craig, Jesse C.</creatorcontrib><creatorcontrib>Poole, David C.</creatorcontrib><creatorcontrib>Billinger, Sandra A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Witte, Emily</au><au>Liu, Yumei</au><au>Ward, Jaimie L.</au><au>Kempf, Katie S.</au><au>Whitaker, Alicen</au><au>Vidoni, Eric D.</au><au>Craig, Jesse C.</au><au>Poole, David C.</au><au>Billinger, Sandra A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise intensity and middle cerebral artery dynamics in humans</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>262</volume><spage>32</spage><epage>39</epage><pages>32-39</pages><issn>1569-9048</issn><issn>1878-1519</issn><eissn>1878-1519</eissn><abstract>•Stimulus-response profiles during exercise are important for understanding control processes.•Middle cerebral artery blood flow velocity increased systematically with work rate.•Amplitude response associated with age and estimated fitness.•Maintaining fitness may benefit cerebrovascular response across aging.
Despite its necessity for understanding healthy brain aging, the influence of exercise intensity on cerebrovascular kinetics is currently unknown. We, therefore characterized middle cerebral artery blood flow velocity (MCAv) kinetics associated with two exercise intensities: low and moderate. We hypothesized that increasing exercise intensity would increase the MCAv amplitude response (Amp) and that age and estimated fitness (V̇O2max) would be related to Amp. Baseline (BL) values were collected for 90-seconds followed by a 6-minute exercise bout. Heart rate, end-tidal CO2, mean arterial pressure and MCAv were recorded throughout. MCAv kinetics were described by Amp, time delay (TD) and time constant (τ). Sixty-four adults completed the study. Amp was greater during moderate compared to low exercise intensity (p < 0.001) while no difference was observed in either TD (p = 0.65) or τ (p = 0.47). Amp was negatively associated with age (p < 0.01) and positively correlated with estimated V̇O2max (p < 0.01). Although Amp declines with age, maintaining higher V̇O2max may benefit the cerebrovascular response to exercise.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30710650</pmid><doi>10.1016/j.resp.2019.01.013</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1618-7207</orcidid><orcidid>https://orcid.org/0000-0001-5181-7131</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Respiratory physiology & neurobiology, 2019-04, Vol.262, p.32-39 |
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| source | Elsevier |
| subjects | Acute exercise Adult Aerobic fitness Aged Aged, 80 and over Aging Aging - physiology Blood Flow Velocity Blood pressure Blood Pressure - physiology Cardiorespiratory Fitness - physiology Cerebral blood flow velocity Exercise - physiology Female Heart Rate - physiology Humans Male Middle Aged Middle cerebral artery Middle Cerebral Artery - diagnostic imaging Middle Cerebral Artery - physiology Ultrasonography, Doppler, Transcranial Young Adult |
| title | Exercise intensity and middle cerebral artery dynamics in humans |
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