Bovine leukemia virus DNA associated with breast cancer in women from South Brazil

Breast cancer is a neoplastic condition with a high morbidity and mortality amongst women worldwide. Recent data linking bovine leukemia virus (BLV) with breast cancer has been contested already. Our study investigated the presence of BLV genome in healthy (n = 72) and cancerous (n = 72) paraffin-em...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.2949-2949, Article 2949
Main Authors: Schwingel, Daniela, Andreolla, Ana P., Erpen, Luana M. S., Frandoloso, Rafael, Kreutz, Luiz C.
Format: Article
Language:English
Subjects:
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Biomarkers
Blood donors
Bovine leukosis
Breast cancer
Deoxyribonucleic acid
DNA
ErbB-2 protein
Genomes
Humanities and Social Sciences
Leukemia
Lymph nodes
Metastases
Morbidity
multidisciplinary
Paraffin
Science
Science (multidisciplinary)
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Summary:Breast cancer is a neoplastic condition with a high morbidity and mortality amongst women worldwide. Recent data linking bovine leukemia virus (BLV) with breast cancer has been contested already. Our study investigated the presence of BLV genome in healthy (n = 72) and cancerous (n = 72) paraffin-embedded samples of breast tissues from women in south Brazil. BLV DNA was found most frequently (30.5%) in breast cancer tissue than in healthy breast (13.9%) (Odds ratio = 2.73; confidence interval = 1.18–6.29; p = 0.027). In contrast, antibodies to BLV were found in a very small percentage of healthy blood donors. There was no association between BLV DNA and other tumor prognostic biological markers such as hormonal receptors, HER2 oncoprotein, proliferation index, metastasis in sentinels lymph nodes, and tumor grade and size. Our findings suggest that BLV should be considered a potential predisposing factor to breast cancer in women.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-39834-7