PathwayConnector: finding complementary pathways to enhance functional analysis

Abstract Summary PathwayConnector is a web-tool that facilitates the construction of complementary pathway-to-pathway networks and subnetworks of them, based on a reference pathway network derived from the rich information available either in KEGG or Reactome database for pathway mapping. Specifical...

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Bibliographic Details
Published in:Bioinformatics 2019-03, Vol.35 (5), p.889-891
Main Authors: Minadakis, George, Zachariou, Margarita, Oulas, Anastasis, Spyrou, George M
Format: Article
Language:English
Subjects:
Applications Notes
Cluster Analysis
Databases, Factual
Software
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Summary:Abstract Summary PathwayConnector is a web-tool that facilitates the construction of complementary pathway-to-pathway networks and subnetworks of them, based on a reference pathway network derived from the rich information available either in KEGG or Reactome database for pathway mapping. Specifically, for a given set of pathways, PathwayConnector (i) finds all the direct connections between them, (ii) adds a minimum set of complementary pathways required to achieve connectivity between the pathways, leading to informative fully connected networks and (ii) provides a series of clustering methods for the further grouping of pathways in to sub-clusters. The proposed web-tool is a simple yet informative tool towards identifying connected groups of pathways that are significantly related to specific diseases. Availability and implementation http://bioinformatics.cing.ac.cy/PathwayConnector Supplementary information Supplementary data are available at Bioinformatics online.
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/bty693