Spatial contribution of hippocampal BOLD activation in high-resolution fMRI

While the vascular origin of the BOLD-fMRI signal is established, the exact neurovascular coupling events contributing to this signal are still incompletely understood. Furthermore, the hippocampal spatial properties of the BOLD activation are not elucidated, although electrophysiology approaches ha...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.3152-3152, Article 3152
Main Authors: Abe, Yoshifumi, Tsurugizawa, Tomokazu, Le Bihan, Denis, Ciobanu, Luisa
Format: Article
Language:English
Subjects:
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Blood vessels
Electrical stimuli
Electrophysiology
Functional magnetic resonance imaging
Hippocampal plasticity
Hippocampus
Humanities and Social Sciences
Life Sciences
Long-term potentiation
Magnetic fields
multidisciplinary
Science
Science (multidisciplinary)
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Summary:While the vascular origin of the BOLD-fMRI signal is established, the exact neurovascular coupling events contributing to this signal are still incompletely understood. Furthermore, the hippocampal spatial properties of the BOLD activation are not elucidated, although electrophysiology approaches have already revealed the precise spatial patterns of neural activity. High magnetic field fMRI offers improved contrast and allows for a better correlation with the underlying neuronal activity because of the increased contribution to the BOLD signal of small blood vessels. Here, we take advantage of these two benefits to investigate the spatial characteristics of the hippocampal activation in a rat model before and after changing the hippocampal plasticity by long-term potentiation (LTP). We found that the hippocampal BOLD signals evoked by electrical stimulation at the perforant pathway increased more at the radiatum layer of the hippocampal CA1 region than at the pyramidal cell layer. The return to the baseline of the hippocampal BOLD activation was prolonged after LTP induction compared with that before most likely due vascular or neurovascular coupling changes. Based on these results, we conclude that high resolution BOLD-fMRI allows the segregation of hippocampal subfields probably based on their underlying vascular or neurovascular coupling features.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-39614-3