Early-Life Exposure to the Chinese Famine Is Associated with Higher Methylation Level in the INSR Gene in Later Adulthood

We examined the association between the China famine exposure in early life and DNA methylation of INSR (hg18, chr19:7110130-7110574) and CPT1A (hg18, chr11: 68286513-68286952) related to growth and metabolism in 235 subjects selected from two provinces in China. The subjects were categorized into p...

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Bibliographic Details
Published in:Scientific reports 2019-03, Vol.9 (1), p.3354-3354, Article 3354
Main Authors: Wang, Zhenghe, Song, Jieyun, Li, Yanhui, Dong, Bin, Zou, Zhiyong, Ma, Jun
Format: Article
Language:English
Subjects:
692/308/174
692/700/2814
Antigens, CD - genetics
Carnitine O-Palmitoyltransferase - genetics
Case-Control Studies
China
Cholesterol
Deoxyribonucleic acid
DNA
DNA Methylation
Eating behavior
Epigenome
Exposure
Famine
Female
Fetuses
Humanities and Social Sciences
Humans
Leukocytes
Male
Meat
Middle Aged
Mucous membrane
multidisciplinary
Pregnancy
Prenatal development
Prenatal experience
Prenatal exposure
Prenatal Exposure Delayed Effects
Receptor, Insulin - genetics
Science
Science (multidisciplinary)
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Summary:We examined the association between the China famine exposure in early life and DNA methylation of INSR (hg18, chr19:7110130-7110574) and CPT1A (hg18, chr11: 68286513-68286952) related to growth and metabolism in 235 subjects selected from two provinces in China. The subjects were categorized into prenatal famine-exposed group and non-exposed group based on their birthdates. DNA methylation at the INSR gene locus was assayed from peripheral white blood cells using the Sequenom’s MassARRAY system. Two dependent samples t -test was used to compare the difference between the exposed group and non-exposed group. DNA methylation level of INSR was higher among individuals who exposed to the China famine in the fetus than that of non-exposed group ( d  = 3.3%, P  = 0.006). A significant interaction between famine exposure and province was observed for INSR ( P interaction  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-38596-6